| Premorbid IQ in patients with functional psychosis and their first-degree relatives. | |
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MedLine Citation:
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PMID: 10728719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous studies have found deficits in premorbid IQ in schizophrenic patients, but it is not clear whether this deficit is shared by (a) patients with other functional psychoses, and (b) relatives of these patients. Ninety-one schizophrenic patients, 66 affective psychotic patients (29 schizoaffective and 37 manic or depressed), and 50 normal control subjects were administered the National Adult Reading Test (NART) which provides an estimate of premorbid IQ. The NART was also completed by 85 first-degree relatives of schizophrenic patients and by 65 first-degree relatives of affective psychotic patients. After adjustments were made for sex, social class, ethnicity and years of education, schizophrenic patients had significantly lower premorbid IQ than their relatives, the affective psychotic patients and controls. Manic and depressed patients had significantly lower NART scores than their first-degree relatives, but schizoaffective patients did not, and neither group differed significantly from controls. There was no significant difference in premorbid IQ between patients who had experienced obstetric complications (OC+) and those who had not (OC-). Both OC+ and OC- schizophrenic patients differed significantly from their relatives, but the disparity was greatest between OC+ patients and their relatives. Relatives of OC+ schizophrenic patients had significantly higher IQ than relatives of OC- schizophrenic patients. |
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Authors:
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C Gilvarry; N Takei; A Russell; T Rushe; D Hemsley; R M Murray |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Schizophrenia research Volume: 41 ISSN: 0920-9964 ISO Abbreviation: Schizophr. Res. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-04-19 Completed Date: 2000-04-19 Revised Date: 2010-09-02 |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 417-29 Citation Subset: IM |
Affiliation:
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Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Bipolar Disorder / diagnosis, genetics* Female Genetic Predisposition to Disease / genetics* Humans Intelligence / genetics* Intelligence Tests / statistics & numerical data Male Middle Aged Phenotype Pregnancy Prenatal Exposure Delayed Effects Psychometrics Psychotic Disorders / diagnosis, genetics* Reference Values Schizophrenia / diagnosis, genetics* Schizotypal Personality Disorder / diagnosis, genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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