Document Detail

Premixed antibiotic bone cement: an in vitro comparison of antimicrobial efficacy.
MedLine Citation:
PMID:  18617361     Owner:  NLM     Status:  MEDLINE    
After Food and Drug Administration (FDA) approval of premixed antibiotic bone cements (polymethylmethacrylate [PMMA]), these products are being used with increasing frequency during revision and primary hip and knee arthroplasties. To date, no studies have compared the antimicrobial efficacy of more than 2 products directly. Using a 7-day modified Kirby-Bauer assay, we assessed the in vitro antibacterial properties of 5 FDA-approved, commercially available antibiotic PMMAs. Significant differences in antimicrobial activity were noted among the antibiotic PMMA products included in this investigation. Antibacterial activity of all products tested was greatest on day 1 and rapidly diminished thereafter. Results of this investigation suggest that the antibacterial efficacies of premixed antibiotic PMMA products are not equivalent.
Matthew W Squire; Brian J Ludwig; Jonathan R Thompson; Jason Jagodzinski; Derek Hall; David Andes
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-07-09
Journal Detail:
Title:  The Journal of arthroplasty     Volume:  23     ISSN:  1532-8406     ISO Abbreviation:  J Arthroplasty     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703515     Medline TA:  J Arthroplasty     Country:  United States    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
University of Wisconsin Department of Orthopedic Surgery, Madison, Wisconsin, USA.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Bacteria / drug effects*
Bone Cements*
Gentamicins / administration & dosage
Microbial Sensitivity Tests
Polymethyl Methacrylate*
Staphylococcus aureus / drug effects
Time Factors
Tobramycin / administration & dosage
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bone Cements; 0/Gentamicins; 32986-56-4/Tobramycin; 9011-14-7/Polymethyl Methacrylate

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