| Premedication with melatonin vs midazolam in anxious children. | |
| | |
MedLine Citation:
|
PMID: 18616492 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: Failure of dental treatment caused by anxiety is a common problem in children. Oral midazolam has been the most commonly used premedication for pediatric patient but the use of midazolam may be associated with paradoxical reactions in children. Melatonin may induce a natural sleepiness and improve sedation. We have investigated premedication with melatonin compared with midazolam in children under nitrous oxide/oxygen (N(2)O/O(2)) sedation for dental treatment. METHODS: In a randomized study, 60 children received either 3 mg of melatonin [Melatonina (3 mg(R)) 60 min before the procedure (n = 15); group I], 0.5 mg.kg(-1) melatonin 60 min before the procedure (n = 15; group II), 0.75 mg.kg(-1) midazolam [Dormicum (15 mg/3 ml (R)) 15 min before the procedure (n = 15); group III] or 3 ml of 0.09 NaCl 15 min (n = 7) or 60 min before the procedure (n = 8; group IV) orally. The children were sedated with 40/60% N(2)O/O(2) inhalation. The heart rate and O(2) saturation were monitored during the treatment period. The level of sedation was assessed according to the Ramsay Sedation Scale. The children's sedation success during dental treatment was classified. The sedation success and other sedation-related events recorded. Comparisons among the four groups were made using one-way anova or Kruskal-Wallis test, and if any significant differences were noted, the Tukey's HSD or Mann-Whitney U-test were used for intergroup comparisons. All differences were considered significant at P < 0.05. RESULTS: The evaluation of sedation success was as follows: group I: satisfactory (n = 1), average satisfactory (n = 4), and unsatisfactory (n = 10); group II: satisfactory (n = 2), average satisfactory (n = 3), and unsatisfactory (n = 10); group III: satisfactory (n = 9), average satisfactory (n = 6); and group IV: satisfactory (n = 1), average satisfactory (n = 3), and unsatisfactory (n = 11). CONCLUSION: In these doses and clinical conditions, melatonin was similar to that of placebo and did not contribute to N(2)O/O(2) sedation of anxious children. |
| | |
Authors:
|
Berrin Isik; Ozgül Baygin; Haluk Bodur |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Paediatric anaesthesia Volume: 18 ISSN: 1460-9592 ISO Abbreviation: Paediatr Anaesth Publication Date: 2008 Jul |
Date Detail:
|
Created Date: 2008-07-11 Completed Date: 2008-10-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9206575 Medline TA: Paediatr Anaesth Country: France |
Other Details:
|
Languages: eng Pagination: 635-41 Citation Subset: IM |
Affiliation:
|
Departments of Oral and Maxillo Facial Surgery, Gazi University Faculty of Dentistry, Ankara, Turkey. berrinisik@gazi.edu.tr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia, Dental
/
methods* Anesthetics, Inhalation / administration & dosage Anesthetics, Intravenous / therapeutic use Central Nervous System Depressants / therapeutic use Child Child Behavior / drug effects Child, Preschool Dental Anxiety / drug therapy* Dental Care for Children / methods* Female Heart Rate / drug effects Humans Male Melatonin / therapeutic use* Midazolam / therapeutic use* Nitrous Oxide / administration & dosage Oxygen / administration & dosage, metabolism Patient Satisfaction / statistics & numerical data Premedication / methods* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Inhalation; 0/Anesthetics, Intravenous; 0/Central Nervous System Depressants; 10024-97-2/Nitrous Oxide; 59467-70-8/Midazolam; 73-31-4/Melatonin; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determining the accuracy of caudal needle placement in children: a comparison of the swoosh test and...
Next Document: The paradoxical image of chemotherapy: a phenomenological description of nurses' experiences of admi...