| Premedication with intravenous ketorolac trometamol (Toradol) in colonoscopy: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 16393218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We conducted a prospective double-blinded placebo-controlled randomized trial to investigate the effect of ketorolac trometamol (KT) administered intravenously as premedication in colonoscopy. METHODS: One hundred and forty patients undergoing colonoscopy were randomized to receive either 60 mg of KT (KT group (KTG), n=70) or placebo (normal saline group (NSG), n=70) intravenously as premedication 30 min prior to procedure. Patient-controlled sedation (PCS) was used as the mode of sedation. Outcome measures included patient self-assessed pain score in a 10-cm unscaled visual analog scale (VAS), endoscopist assessment of patient pain score in VAS, patient's willingness to repeat colonoscopy, administered and demanded doses of PCS, patient satisfaction score in VAS, and hemodynamic changes during and after the procedure. RESULTS: The mean patient self-assessed pain score (SD) during procedure was significantly lower in KTG than NSG: 5.08 (2.74) vs 6.62 (2.45); p=0.001. The mean endoscopist assessment of patient pain score (SD) was significantly lower in KTG than NSG as well: 3.99 (2.80) vs 5.28 (2.71); p=0.006. More patients in KTG were willing to repeat procedure as compared with NSG (80.0%vs 57.1%; p=0.004). No significant difference was found in the administered and demanded doses of PCS, mean satisfactory scores and hemodynamic changes in both groups. No serious complication related to intravenous (IV) KT was noted. CONCLUSIONS: Premedication with IV KT (Toradol) improves pain control during colonoscopy with no associated serious complications. |
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Authors:
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Wilfred Lik-Man Mui; Wing-Hang Kwong; Anthony C N Li; Alex C M Au Yeung; Chi-Ming Poon; Philip Wai-Yan Chiu; Yuk-Ling Chan; Heng-Tat Leong; Enders K W Ng |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 100 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-01-05 Completed Date: 2006-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 2669-73 Citation Subset: IM |
Affiliation:
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Department of Surgery and Endoscopy Centers, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Academic Medical Centers Adolescent Adult Aged Colonoscopy / methods* Cyclooxygenase Inhibitors / therapeutic use* Dose-Response Relationship, Drug Double-Blind Method Drug Administration Schedule Female Follow-Up Studies Hong Kong Humans Infusions, Intravenous Ketorolac Tromethamine / therapeutic use* Male Middle Aged Pain / prevention & control Pain Measurement Patient Satisfaction Premedication* Probability Prospective Studies Reference Values Statistics, Nonparametric Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cyclooxygenase Inhibitors; 74103-07-4/Ketorolac Tromethamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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