Document Detail

Premedication with intravenous ketorolac trometamol (Toradol) in colonoscopy: a randomized controlled trial.
MedLine Citation:
PMID:  16393218     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We conducted a prospective double-blinded placebo-controlled randomized trial to investigate the effect of ketorolac trometamol (KT) administered intravenously as premedication in colonoscopy. METHODS: One hundred and forty patients undergoing colonoscopy were randomized to receive either 60 mg of KT (KT group (KTG), n=70) or placebo (normal saline group (NSG), n=70) intravenously as premedication 30 min prior to procedure. Patient-controlled sedation (PCS) was used as the mode of sedation. Outcome measures included patient self-assessed pain score in a 10-cm unscaled visual analog scale (VAS), endoscopist assessment of patient pain score in VAS, patient's willingness to repeat colonoscopy, administered and demanded doses of PCS, patient satisfaction score in VAS, and hemodynamic changes during and after the procedure. RESULTS: The mean patient self-assessed pain score (SD) during procedure was significantly lower in KTG than NSG: 5.08 (2.74) vs 6.62 (2.45); p=0.001. The mean endoscopist assessment of patient pain score (SD) was significantly lower in KTG than NSG as well: 3.99 (2.80) vs 5.28 (2.71); p=0.006. More patients in KTG were willing to repeat procedure as compared with NSG (80.0%vs 57.1%; p=0.004). No significant difference was found in the administered and demanded doses of PCS, mean satisfactory scores and hemodynamic changes in both groups. No serious complication related to intravenous (IV) KT was noted. CONCLUSIONS: Premedication with IV KT (Toradol) improves pain control during colonoscopy with no associated serious complications.
Wilfred Lik-Man Mui; Wing-Hang Kwong; Anthony C N Li; Alex C M Au Yeung; Chi-Ming Poon; Philip Wai-Yan Chiu; Yuk-Ling Chan; Heng-Tat Leong; Enders K W Ng
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  100     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2669-73     Citation Subset:  IM    
Department of Surgery and Endoscopy Centers, The Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China.
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MeSH Terms
Academic Medical Centers
Colonoscopy / methods*
Cyclooxygenase Inhibitors / therapeutic use*
Dose-Response Relationship, Drug
Double-Blind Method
Drug Administration Schedule
Follow-Up Studies
Hong Kong
Infusions, Intravenous
Ketorolac Tromethamine / therapeutic use*
Middle Aged
Pain / prevention & control
Pain Measurement
Patient Satisfaction
Prospective Studies
Reference Values
Statistics, Nonparametric
Treatment Outcome
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 74103-07-4/Ketorolac Tromethamine

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