Document Detail


Prematurity and programming: are there later metabolic sequelae?
MedLine Citation:
PMID:  18370756     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Low birth weight has a well-established association with early-onset insulin resistance and a later risk of adult diseases, including all aspects of the metabolic syndrome. Although most studies to date have focused on term low-birth-weight subjects, other low-birth-weight groups (such as prematurely born children) need evaluating. In this review, we demonstrate that prematurely born children have a metabolic profile very similar to term small-forgestational- age (SGA) children and may have a similar increased risk of the metabolic syndrome later in life. We propose mechanisms (in particular, epigenetic alterations and the higher risk of hypomethylation in prematurely born children) by which this could occur.
Authors:
Paul L Hofman; Fiona Regan; Craig A Jefferies; Wayne S Cutfield
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Metabolic syndrome and related disorders     Volume:  4     ISSN:  1557-8518     ISO Abbreviation:  Metab Syndr Relat Disord     Publication Date:  2006  
Date Detail:
Created Date:  2008-03-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101150318     Medline TA:  Metab Syndr Relat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-12     Citation Subset:  -    
Affiliation:
Liggins Institute, University of Auckland, Auckland, New Zealand.
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