| Prematurity prevention: the role of acute tocolysis. | |
| | |
MedLine Citation:
|
PMID: 19996866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: The preterm birth rate in the United States remains at an all-time high and continues to rise. Acute tocolysis has potential to delay preterm birth for 48 h, the critical period of antenatal steroid administration, or to arrest an episode of preterm labor, thus delaying birth and improving neonatal outcomes. It is therefore paramount that medical providers remain up-to-date regarding the usefulness, indications and contraindications, and side-effects and adverse effects of all tocolytics. RECENT FINDINGS: Magnesium sulfate remains the most common tocolyic agent in the United States. Recent evidence comparing oral nifedipine with magnesium sulfate suggests equal efficacy with fewer maternal side-effects, thus supporting this oral medication as first-line treatment. This review will summarize the most common acute tocolytic drugs, their methods of action, and clinical data regarding their utility. SUMMARY: All tocolytic medications have side-effects, some of them potentially life-threatening. Decisions regarding whether to use a tocolytic and which tocolytic to use require the diagnosis of preterm labor, knowledge of the patient's gestational age, medical conditions, and cost. Once tocolysis is initiated, attention must be paid to the patient's response, side-effects, and adverse events. Larger studies are needed which incorporate, in addition to efficacy, data on safety and side-effect profiles and cost. |
| | |
Authors:
|
Yair J Blumenfeld; Deirdre J Lyell |
Related Documents
:
|
10930706 - The aphrodisiac and adaptogenic properties of ginseng. 7196546 - Amitriptyline-induced ophthalmoplegia. 15043806 - Idiopathic generalized epilepsy. 20727486 - Medical treatment of pediatric status epilepticus. 21735806 - Specialty choices of medical students and house officers in karachi, pakistan. 16144586 - Controversies in the medical clearance of recreational scuba divers: updates on asthma,... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Current opinion in obstetrics & gynecology Volume: 21 ISSN: 1473-656X ISO Abbreviation: Curr. Opin. Obstet. Gynecol. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-12-09 Completed Date: 2010-02-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9007264 Medline TA: Curr Opin Obstet Gynecol Country: England |
Other Details:
|
Languages: eng Pagination: 136-41 Citation Subset: IM |
Affiliation:
|
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, Stanford University, 300 Pasteur Drive, Room HH333, Stanford, California 94305, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Administration, Oral Calcium Channel Blockers / therapeutic use Clinical Trials as Topic Female Humans Magnesium Sulfate / therapeutic use Nifedipine / therapeutic use Obstetric Labor, Premature / prevention & control* Obstetrics / methods* Oxytocin / metabolism Pregnancy Premature Birth / prevention & control* Prostaglandin Antagonists / therapeutic use Tocolysis / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Calcium Channel Blockers; 0/Prostaglandin Antagonists; 21829-25-4/Nifedipine; 50-56-6/Oxytocin; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Risks and management of obesity in pregnancy: current controversies.
Next Document: Prematurity prevention: the role of cerclage.