Document Detail


Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009).
MedLine Citation:
PMID:  22499837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Congenital toxoplasmosis is a severe, life-altering disease in the United States. A recently developed enzyme-linked immunosorbent assay (ELISA) distinguishes Toxoplasma gondii parasite types (II and not exclusively II [NE-II]) by detecting antibodies in human sera that recognize allelic peptide motifs of distinct parasite types.
METHODS: ELISA determined parasite serotype for 193 congenitally infected infants and their mothers in the National Collaborative Chicago-based Congenital Toxoplasmosis Study (NCCCTS), 1981-2009. Associations of parasite serotype with demographics, manifestations at birth, and effects of treatment were determined.
RESULTS: Serotypes II and NE-II occurred in the United States with similar proportions during 3 decades. For persons diagnosed before or at birth and treated in infancy, and persons diagnosed after 1 year of age who missed treatment in infancy, proportions were similar (P = .91). NE-II serotype was more common in hot, humid regions (P = .02) but was also present in other regions. NE-II serotype was associated with rural residence (P < .01), lower socioeconomic status (P < .001), and Hispanic ethnicity (P < .001). Prematurity (P = .03) and severe disease at birth (P < .01) were associated with NE-II serotype. Treatment with lower and higher doses of pyrimethamine with sulfadizine improved outcomes relative to those outcomes of persons in the literature who did not receive such treatment.
CONCLUSIONS: Type II and NE-II parasites cause congenital toxoplasmosis in North America. NE-II serotype was more prevalent in certain demographics and associated with prematurity and severe disease at birth. Both type II and NE-II infections improved with treatment.
CLINICAL TRIALS REGISTRATION: NCT00004317.
Authors:
Rima McLeod; Kenneth M Boyer; Daniel Lee; Ernest Mui; Kristen Wroblewski; Theodore Karrison; A Gwendolyn Noble; Shawn Withers; Charles N Swisher; Peter T Heydemann; Mari Sautter; Jane Babiarz; Peter Rabiah; Paul Meier; Michael E Grigg;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't     Date:  2012-04-11
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  54     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-10     Completed Date:  2012-08-29     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1595-605     Citation Subset:  IM    
Affiliation:
Department of Opthalmology and Visual Sciences, University of Chicago, Chicago, Illinois 60637, USA. rmcleod@midway.uchicago.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00004317
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alleles
Antibodies, Protozoan / blood
Child
Child, Preschool
Enzyme-Linked Immunosorbent Assay
Female
Humans
Infant
Infant, Newborn
Male
Pregnancy
Prevalence
Serotyping
Toxoplasma / classification*,  pathogenicity*
Toxoplasmosis, Congenital / epidemiology*,  parasitology*,  pathology
United States / epidemiology
Virulence
Grant Support
ID/Acronym/Agency:
R01AI027530/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Protozoan
Investigator
Investigator/Affiliation:
Dianna Bardo / ; Delilah Burrowes / ; Audrey Cameron / ; Ellen Holfels / ; Paul Latkany / ; Douglas Mack / ; John Marcinak / ; James McAuley / ; Marilyn Mets / ; Sanford Meyers / ; William Mieler / ; Dushyant Patel / ; Jeanne Perkins / ; James Rago / ; Nancy Roizen / ; Lazlo Stein / ; Andrew Suth / ; Marie Weissbourd / ; Teri Hull / ; Kathy Zebracki / ; Caitlin Roache /
Comments/Corrections
Comment In:
Clin Infect Dis. 2012 Jun;54(11):1606-7   [PMID:  22499838 ]

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