| Prematurity and Severity Are Associated With Toxoplasma gondii Alleles (NCCCTS, 1981-2009). | |
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MedLine Citation:
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PMID: 22499837 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background. Congenital toxoplasmosis is a severe, life-altering disease in the United States. A recently developed enzyme-linked immunosorbent assay (ELISA) distinguishes Toxoplasma gondii parasite types (II and not exclusively II [NE-II]) by detecting antibodies in human sera that recognize allelic peptide motifs of distinct parasite types.Methods. ELISA determined parasite serotype for 193 congenitally infected infants and their mothers in the National Collaborative Chicago-based Congenital Toxoplasmosis Study (NCCCTS), 1981-2009. Associations of parasite serotype with demographics, manifestations at birth, and effects of treatment were determined.Results. Serotypes II and NE-II occurred in the United States with similar proportions during 3 decades. For persons diagnosed before or at birth and treated in infancy, and persons diagnosed after 1 year of age who missed treatment in infancy, proportions were similar (P = .91). NE-II serotype was more common in hot, humid regions (P = .02) but was also present in other regions. NE-II serotype was associated with rural residence (P < .01), lower socioeconomic status (P < .001), and Hispanic ethnicity (P < .001). Prematurity (P = .03) and severe disease at birth (P < .01) were associated with NE-II serotype. Treatment with lower and higher doses of pyrimethamine with sulfadizine improved outcomes relative to those outcomes of persons in the literature who did not receive such treatment.Conclusions. Type II and NE-II parasites cause congenital toxoplasmosis in North America. NE-II serotype was more prevalent in certain demographics and associated with prematurity and severe disease at birth. Both type II and NE-II infections improved with treatment.Clinical Trials Registration. NCT00004317. |
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Authors:
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Rima McLeod; Kenneth M Boyer; Daniel Lee; Ernest Mui; Kristen Wroblewski; Theodore Karrison; A Gwendolyn Noble; Shawn Withers; Charles N Swisher; Peter T Heydemann; Mari Sautter; Jane Babiarz; Peter Rabiah; Paul Meier; Michael E Grigg; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-11 |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: - ISSN: 1537-6591 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments ofOphthalmology and Visual Sciences. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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