Document Detail


Prematurity and low birth weight as potential mediators of higher stillbirth risk in mixed black/white race couples.
MedLine Citation:
PMID:  20235877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Although births of multiracial and multiethnic infants are becoming more common in the United States, little is known about birth outcomes and risks for adverse events. We evaluated risk of fetal death for mixed race couples compared with same race couples and examined the role of prematurity and low birth weight as potential mediating risk factors.
METHODS: We performed a retrospective cohort analysis using data from the 1998-2002 California Birth Cohort to evaluate the odds of fetal death, low birth weight, and prematurity for couples with a mother and father who were categorized as either being of same or different racial groups. Risk of prematurity (birth prior to 37 weeks gestation) and low birth weight (<2500 g) were also tested to see if the model could explain variations among groups.
RESULTS: The analysis included approximately 1.6 million live births and 1749 stillbirths. In the unadjusted model, compared with two white parents, black/black and black/white couples had a significantly higher risk of fetal death. When all demographic, social, biological, genetic, congenital, and procedural risk factors except gestational age and birth weight were included, the odds ratios (OR) were all still significant. Black/black couples had the highest level of risk (OR 2.11, CI 1.77-2.51), followed by black mother/white father couples (OR 2.01, CI 1.16-3.48), and white mother/black father couples (OR 1.84, CI 1.33-2.54). Virtually all of the higher risk of fetal death was explainable by higher rates of low birth weight and prematurity.
CONCLUSIONS: Mixed race black and white couples face higher odds of prematurity and low birth weight, which appear to contribute to the substantially higher demonstrated risk for stillbirth. There are likely additional unmeasured factors that influence birth outcomes for mixed race couples.
Authors:
Katherine J Gold; Sonya M DeMonner; Paula M Lantz; Rodney A Hayward
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of women's health (2002)     Volume:  19     ISSN:  1931-843X     ISO Abbreviation:  J Womens Health (Larchmt)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-26     Completed Date:  2012-04-16     Revised Date:  2014-04-11    
Medline Journal Info:
Nlm Unique ID:  101159262     Medline TA:  J Womens Health (Larchmt)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  767-73     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group*
California
Cohort Studies
European Continental Ancestry Group*
Family Characteristics / ethnology*
Female
Fetal Death / epidemiology
Humans
Infant, Low Birth Weight
Infant, Newborn
Male
Pregnancy
Premature Birth / epidemiology,  ethnology*
Retrospective Studies
Risk Assessment
Stillbirth / epidemiology,  ethnology*
Young Adult
Grant Support
ID/Acronym/Agency:
K12 HD001438/HD/NICHD NIH HHS; K12 HD001438-08/HD/NICHD NIH HHS; K23 MH085882-02/MH/NIMH NIH HHS
Comments/Corrections

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