Document Detail

Premature weaning-induced changes of cholesterol metabolism in guinea pigs.
MedLine Citation:
PMID:  4037078     Owner:  NLM     Status:  MEDLINE    
Premature weaning in animals causes higher serum cholesterol levels and a relative inability to handle cholesterol challenge in adult life. The mechanisms responsible for these delayed effects of premature weaning are not clear. The aims of this investigation were to 1) determine the effect of premature weaning on the activity of hepatic cholesterol 7 alpha-hydroxylase and plasma cholesterol changes and 2) determine whether addition of cholesterol to the diet will restore premature weaning-induced changes. Premature weaning did not prevent the phenomenon of neonatal hypercholesterolemia noted in day 5 of normally weaned guinea pigs. At day 10, prematurely weaned animals had lower serum cholesterol when compared with normally weaned animals. Premature weaning caused (without or with cholesterol in diet) a significant decrease in the hepatic activity of cholesterol 7 alpha-hydroxylase, and this difference persisted (after 1 mo) when fed the stock diet. These studies demonstrate 1) premature weaning on day 2 does not prevent neonatal hypercholesterolemia on day 5, 2) premature weaning causes a decrease in hepatic cholesterol 7 alpha-hydroxylase activity that persists into adult life, and 3) dietary cholesterol intake in early life is unable to negate premature weaning-induced changes.
M T Subbiah; R L Yunker; A Menkhaus; B Poe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  249     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-10-10     Completed Date:  1985-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E251-6     Citation Subset:  IM    
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MeSH Terms
Bile Acids and Salts / metabolism
Cholesterol / blood,  metabolism*
Cholesterol 7-alpha-Hydroxylase / metabolism
Feces / analysis
Guinea Pigs
Hydrocortisone / blood
Microsomes, Liver / enzymology*
Sterols / analysis
Grant Support
Reg. No./Substance:
0/Bile Acids and Salts; 0/Sterols; 50-23-7/Hydrocortisone; 57-88-5/Cholesterol; EC 7-alpha-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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