Document Detail

Premature separation of centromeres in marrow chromosomes from an untreated patient with acute myelogenous leukemia.
MedLine Citation:
PMID:  3855690     Owner:  NLM     Status:  MEDLINE    
Cytogenetic studies in an untreated patient with acute myelogenous leukemia revealed that greater than 60% of his marrow metaphases had pronounced anomalies in the centromere region. In the least affected chromosomes, the centromere appeared as a nonstaining hole, whereas in the most affected chromosomes, it appeared that the centromere segment had prematurely migrated at right angles to the telomeric portions. The population of mitoses exhibiting premature separation of the centromeres was reduced to virtually none during periods of drug induced remission. Our findings suggest that cytogenetic changes in malignant myeloid cells may be characterized by defects in centromere separation, as well as by alternations in karyotype.
L G Littlefield; E E Joiner; A M Sayer
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cancer genetics and cytogenetics     Volume:  16     ISSN:  0165-4608     ISO Abbreviation:  Cancer Genet. Cytogenet.     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-15     Completed Date:  1985-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909240     Medline TA:  Cancer Genet Cytogenet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-16     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / ultrastructure
Centromere / ultrastructure*
Chromosome Aberrations*
Chromosomes / ultrastructure*
Leukemia, Myeloid, Acute / blood,  drug therapy,  genetics*
Leukocyte Count
Middle Aged
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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