Document Detail

Premature rupture of membranes and early mortality among triplets in the United States.
MedLine Citation:
PMID:  14687736     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We investigated the relationship between premature rupture of the membranes (PROM) and early mortality among triplets in the United States. STUDY DESIGN: Analysis was conducted on matched and linked triplet sets born to mothers in the United States between 1995 and 1997. The generalized estimating equation framework was used to generate odds ratios after capturing the effects of sibling correlations within triplet clusters. RESULTS: Triplets exposed to PROM were twice as likely to experience stillbirth (OR=2.17, 95% CI [1.26-3.41]), neonatal death (OR=2.23, 95% CI [1.70-3.0]) and infant death (OR=2.21, 95% CI [1.72-2.85]), as compared to those who did not. The population-attributable risk for early mortality due to PROM was 11-12%. CONCLUSIONS: Triplets associated with PROM had a significantly higher level of early mortality than those without. Assuming a causal relationship, 11-12% of all early deaths among triplets in the United States are accounted for by PROM.
Sibylle Kristensen; Hamisu M Salihu; Greg R Alexander
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  112     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-02-26     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  36-42     Citation Subset:  IM    
Division of Geographic Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
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MeSH Terms
Case-Control Studies
Cause of Death*
Confidence Intervals
Fetal Death*
Fetal Membranes, Premature Rupture / complications*,  mortality
Infant Mortality / trends*
Infant, Newborn
Maternal Age
Odds Ratio
Pregnancy, High-Risk
Pregnancy, Multiple
Reference Values
Retrospective Studies
Risk Assessment
Risk Factors
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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