Document Detail


Premature red blood cells have decreased aggregation and enhanced aggregability.
MedLine Citation:
PMID:  18405459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preterm infants are highly susceptible to ischemic damage. This damage is most obvious in the brain, retina, and gastrointestinal tract. Studies focusing on the rheological properties of premature red blood cells (pRBCs) have consistently shown minimal or no RBC aggregation. Previously, measurements of pRBC aggregation kinetics indicated that specific plasma properties are responsible for the decreased RBC aggregation observed in the neonates, but that their specific RBC properties do not affect it. However, the strength of interaction in the pRBC aggregates as a function of medium composition has not been tested. In our previous research, we described clinically relevant parameters, that is, the aggregate resistance to disaggregation by flow. With the help of a cell flow property analyzer (CFA), we can monitor RBC aggregation by direct visualization of its dynamics during flow. We used the CFA to examine pRBC (from 9 premature babies) in the natural plasma and in PBS buffer supplemented with dextran (500 kDa) to distinguish between RBC intrinsic-cellular and plasma factors. pRBCs suspended in the native plasma showed minimal or no aggregation in comparison to normal adult RBC. When we transferred pRBCs from the same sample to the dextran solution, enhanced resistance to disaggregation by flow was apparent.
Authors:
D Arbell; B Orkin; B Bar-Oz; G Barshtein; S Yedgar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-04-15
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  58     ISSN:  1880-6546     ISO Abbreviation:  J Physiol Sci     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-10-16     Revised Date:  2008-12-29    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  161-5     Citation Subset:  IM    
Affiliation:
Department of Pediatric Surgery, Hebrew University-Hadassah, Jerusalem 91120, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Dextrans / pharmacology
Erythrocyte Aggregation / physiology*
Erythrocytes / cytology*,  drug effects
Humans
Infant, Newborn
Infant, Premature
Plasma / cytology
Plasma Substitutes / pharmacology
Chemical
Reg. No./Substance:
0/Plasma Substitutes; 9004-54-0/Dextrans

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