| Premature parturition is characterized by in utero activation of the fetal immune system. | |
MedLine Citation:
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PMID: 7485345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: At birth the fetus emerges from a sterile environment into a nonsterile one. This process is associated with activation of the fetal immune system which protects the fetus against infection in the newborn period. We conducted this study to determine whether activation of the monocyte-neutrophil system occurs in fetuses before premature birth. STUDY DESIGN: Forty patients in premature labor with intact membranes underwent cordocentesis for research purposes. Fetal blood was analyzed with the use of flow cytometry to measure the cell surface markers CD11c, CD13, CD15, and CD67, which are associated with monocyte and neutrophil activation, and CD14 and CD63, which were used as controls. RESULTS: Twenty-eight percent (11/40) of the infants were delivered prematurely within 72 hours of entering the study while the remainder were delivered at term. Our data clearly indicate that premature infants delivered within 72 hours had a higher percentage of CD11c, CD13, CD15, and CD67 than those delivered at term. In contrast, there were no significant differences in the percentages of CD14 and CD63. CONCLUSION: Activation of the monocyte-neutrophil system exists in fetuses destined for premature delivery. These findings indicate that premature parturition is associated with in utero immune system activation. |
Authors:
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S M Berry; R Romero; R Gomez; K S Puder; F Ghezzi; D B Cotton; D W Bianchi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 173 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-12-05 Completed Date: 1995-12-05 Revised Date: 2010-10-20 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1315-20 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, MI 48201-1498, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antigens, CD / analysis Antigens, CD13 / analysis Antigens, CD14 / analysis Antigens, CD15 / analysis Antigens, Neoplasm* Cell Adhesion Molecules* Cell Separation Female Fetal Blood / immunology Fetus / immunology* Flow Cytometry Humans Macrophage Activation* Membrane Glycoproteins / analysis Neutrophil Activation* Obstetric Labor, Premature / immunology* Platelet Membrane Glycoproteins / analysis Pregnancy |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD14; 0/Antigens, CD15; 0/Antigens, Neoplasm; 0/CD63 antigen; 0/Cell Adhesion Molecules; 0/Membrane Glycoproteins; 0/Platelet Membrane Glycoproteins; EC 3.4.11.2/Antigens, CD13 |
| Comments/Corrections | |
Comment In:
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Am J Obstet Gynecol. 1996 Aug;175(2):501-2
[PMID:
8765277
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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