Document Detail

Premature parturition is characterized by in utero activation of the fetal immune system.
MedLine Citation:
PMID:  7485345     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: At birth the fetus emerges from a sterile environment into a nonsterile one. This process is associated with activation of the fetal immune system which protects the fetus against infection in the newborn period. We conducted this study to determine whether activation of the monocyte-neutrophil system occurs in fetuses before premature birth. STUDY DESIGN: Forty patients in premature labor with intact membranes underwent cordocentesis for research purposes. Fetal blood was analyzed with the use of flow cytometry to measure the cell surface markers CD11c, CD13, CD15, and CD67, which are associated with monocyte and neutrophil activation, and CD14 and CD63, which were used as controls. RESULTS: Twenty-eight percent (11/40) of the infants were delivered prematurely within 72 hours of entering the study while the remainder were delivered at term. Our data clearly indicate that premature infants delivered within 72 hours had a higher percentage of CD11c, CD13, CD15, and CD67 than those delivered at term. In contrast, there were no significant differences in the percentages of CD14 and CD63. CONCLUSION: Activation of the monocyte-neutrophil system exists in fetuses destined for premature delivery. These findings indicate that premature parturition is associated with in utero immune system activation.
S M Berry; R Romero; R Gomez; K S Puder; F Ghezzi; D B Cotton; D W Bianchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  173     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2010-10-20    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1315-20     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Wayne State University/Hutzel Hospital, Detroit, MI 48201-1498, USA.
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MeSH Terms
Antigens, CD / analysis
Antigens, CD13 / analysis
Antigens, CD14 / analysis
Antigens, CD15 / analysis
Antigens, Neoplasm*
Cell Adhesion Molecules*
Cell Separation
Fetal Blood / immunology
Fetus / immunology*
Flow Cytometry
Macrophage Activation*
Membrane Glycoproteins / analysis
Neutrophil Activation*
Obstetric Labor, Premature / immunology*
Platelet Membrane Glycoproteins / analysis
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD14; 0/Antigens, CD15; 0/Antigens, Neoplasm; 0/CD63 antigen; 0/Cell Adhesion Molecules; 0/Membrane Glycoproteins; 0/Platelet Membrane Glycoproteins; EC, CD13
Comment In:
Am J Obstet Gynecol. 1996 Aug;175(2):501-2   [PMID:  8765277 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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