Document Detail

Premature ovarian failure in suspected Whipple's disease.
MedLine Citation:
PMID:  18078849     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Whipple's disease is a relapsing systemic infectious disease probably caused by the Gram-positive bacillus Tropheryma whippelii. The diagnosis can be established based on the characteristic histopathological features found in the affected organ (foamy macrophages with a coarsely granular cytoplasm, which stains with PAS, and by means of polymerase chain reaction (PCR) technology). CASE REPORT: We report a case of a 23-year-old woman affected by suspected Whipple's disease. She presented encephalopathy and neuropathy with inveterate hyperpyrexia and alteration of the hypothalamic-pituitary-ovary axe. She was amenorrheic because of an hypergonadotropic hypogonadism. DISCUSSION: This hypogonadism is possibly due to follicular depletion caused by inveterate hyperpyrexia or T. whipplii localization.
Stefano Ferrari; Francesca Di Puppo; Paola Persico; Augusto Ferrari
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  88     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1676.e13-4     Citation Subset:  IM    
Ob-Gyn Department, Vita-Salute University, H San Raffaele, Milan, Italy.
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MeSH Terms
Hypogonadism / diagnosis,  etiology
Ovarian Failure, Premature / diagnosis,  etiology*
Whipple Disease / complications*,  diagnosis

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