Document Detail


Premature ovarian failure and androgen receptor gene CAG repeat lengths weighted by X chromosome inactivation patterns.
MedLine Citation:
PMID:  18281036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The CAG repeat lengths weighted by X-inactivation ratios were significantly shorter in 58 Japanese patients with premature ovarian failure (POF) than in 42 age-matched control females with normal menses. The results suggest that short CAG repeats with a relatively high androgen receptor function may constitute a susceptibility factor for the development of POF.
Authors:
Fumihiro Sugawa; Yuka Wada; Tetsuo Maruyama; Hiroshi Uchida; Bunpei Ishizuka; Tsutomu Ogata
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-20
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-52     Citation Subset:  IM    
Affiliation:
Department of Endocrinology and Metabolism, National Research Institute for Child Health and Development, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group / genetics
Case-Control Studies
Estradiol / blood
Female
Follicle Stimulating Hormone, Human / blood
Gene Frequency
Genetic Predisposition to Disease
Humans
Japan
Luteinizing Hormone / blood
Middle Aged
Ovarian Failure, Premature / blood,  genetics*
Phenotype
Receptors, Androgen / genetics*
Risk Factors
Trinucleotide Repeats*
X Chromosome Inactivation*
Young Adult
Chemical
Reg. No./Substance:
0/AR protein, human; 0/Follicle Stimulating Hormone, Human; 0/Receptors, Androgen; 50-28-2/Estradiol; 9002-67-9/Luteinizing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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