Document Detail

Premature luteal regression in a pregnant mare and subsequent pregnancy maintenance with the use of oral altrenogest.
MedLine Citation:
PMID:  22413930     Owner:  NLM     Status:  MEDLINE    
Premature luteal demise or luteal insufficiency is not well characterised as a cause of pregnancy loss in domestic species, including horses. In this report, a mare inseminated with cooled-transported semen at our facility returned for a routine pregnancy diagnosis at 15 days post ovulation. Ultrasonography per rectum revealed endometrial oedema and the absence of visual indication of a corpus luteum on either ovary. Nonetheless, an embryonic vesicle small for the gestational age was identified. Daily oral altrenogest treatment was implemented immediately. Serum progesterone concentration was 0.67 ng/ml, which is below the threshold considered adequate for pregnancy maintenance in the mare. Examinations were repeated at 17, 25, 30, 39, 49, 72 and 120 days post ovulation. At 25 days post ovulation the embryonic vesicle presented normal development for the gestational age. In addition, sequential blood samples were collected to measure progesterone, equine chorionic gonadotrophin and oestrone sulphate concentrations. Although progesterone concentration did not exceed 2 ng/ml until 72 days post ovulation, all other results were unremarkable and a healthy filly was born uneventfully at 344 days post ovulation.
I F Canisso; K A Beltaire; S J Bedford-Guaus
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-13
Journal Detail:
Title:  Equine veterinary journal     Volume:  45     ISSN:  2042-3306     ISO Abbreviation:  Equine Vet. J.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-05-29     Revised Date:  2013-07-20    
Medline Journal Info:
Nlm Unique ID:  0173320     Medline TA:  Equine Vet J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Copyright Information:
© 2012 EVJ Ltd.
Section of Theriogenology, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, New York, NY, USA.
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MeSH Terms
Abortion, Veterinary / prevention & control
Administration, Oral
Chorionic Gonadotropin / blood
Corpus Luteum Maintenance / drug effects*
Estrone / analogs & derivatives,  blood
Progesterone / blood
Trenbolone Acetate / administration & dosage,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Progest; 10161-33-8/Trenbolone Acetate; 53-16-7/Estrone; 57-83-0/Progesterone; 850-52-2/altrenogest; QTL48N278K/estrone sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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