Document Detail


Premature lambs rescued from respiratory failure with natural surfactant: clinical and biophysical correlates.
MedLine Citation:
PMID:  6920645     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-four Western mixed breed lambs were delivered prematurely at 120 days gestational age (term = 150 days). Four lambs were sacrificed at birth, and four lambs were sacrificed with the onset of respiratory failure (PCO2 greater than 80 torr) at about 30 min of age. The remaining lambs were treated by tracheal instillation with 50 mg of natural sheep surfactant lipid/kg body weight. These lambs were sacrificed 10 min, 40 min, 1.5 h and 3 h after surfactant treatment. Frequent blood gas and compliance measurements documented the clinical responses of the lambs. Lungs from treated lambs showed large increase relative to untreated lungs in air volumes as assessed by pressure-volume curves and by histology. However, the pressure-volume and histologic measurements did not distinguish between the posttreatment groups of lambs. Minimum surface tensions of alveolar washes fell from greater than 30 dynes/cm to 6.3 dynes/cm 10 min after treatment and again rose to 21.6 dynes/cm within 3 h. Minimum surface tensions correlated well with the PO2 values but not with the PCO2 values measured before sacrifice. The combination of dilated distal airways and atelectasis resulted from increasing surface tensions with time and mechanical ventilation and may explain the clinical deterioration without much change in the volume of gas within the airways.
Authors:
H Jacobs; A Jobe; M Ikegami; T Glatz; S J Jones; L Barajas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  16     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Humans
Infant, Newborn
Lung / pathology
Lung Compliance
Pregnancy
Pulmonary Surfactants / therapeutic use*
Pulmonary Ventilation
Respiratory Distress Syndrome, Newborn / pathology,  physiopathology*,  therapy
Sheep
Surface Tension
Grant Support
ID/Acronym/Agency:
HD-12714/HD/NICHD NIH HHS; HD-HL-00252/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Pulmonary Surfactants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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