Document Detail


Premature labor. I. Prostaglandin precursors in human placental membranes.
MedLine Citation:
PMID:  7243097     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Amnion and chorion from premature and term placentas after both spontaneous labor and elective cesarean section were assayed for phospholipids and fatty acid composition by 2-dimensional thin-layer chromatography and gas-liquid chromatography. In preterm placental phospholipids, phosphorus concentrations were higher in amnion than in chorion, whereas at term the membranes were similar owing to an increase in phospholipid concentration in the chorion late in gestation. PHosphatidylcholine (PC) accounted for 47% of the total phospholipid phosphorus, followed by sphingomyelin at 20%, phosphatidylethanolamine (PE) at 15%, phosphatidylserine (PS) at 12%, and phosphatidylinositol (PI) at 5%. These percentages were similar for amnion and chorion and they did not change during gestation. The percentage of arachidonic acid (AA) was higher in PS (40 to 65%) than in PE (30 to 53%) and PC (10 to 13%). The percentage of AA was significantly higher in PC, PE, and PS from the amnion in premature pregnancies than in those of the premature chorion. At term, these amnionic and chorionic phospholipids had similar concentrations of AA owing to a significant increase in AA in the chorion late in gestation. Amnionic PE from term and preterm elective cesarean section had a significantly higher percentage of AA than that from preterm and term labor. These data suggest that AA is consumed during labor and that amnionic phospholipids, particularly PE, may be its principal source. The amnion seems to be more important for the storage of AA than the chorion, particularly in preterm pregnancies in which the concentrations of phospholipids and the percentages of AA in PC, PE, and PS were significantly higher than in the chorion.
Authors:
V Curbelo; R Bejar; K Benirschke; L Gluck
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  57     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-08-27     Completed Date:  1981-08-27     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-8     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Amnion / analysis*
Arachidonic Acids / analysis
Chorion / analysis*
Chromatography, Thin Layer
Fatty Acids / analysis*
Female
Glycerophosphates / analysis*
Humans
Obstetric Labor, Premature / metabolism*
Pregnancy
Pregnancy Trimester, Third
Grant Support
ID/Acronym/Agency:
HD 10622/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Fatty Acids; 0/Glycerophosphates

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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