Document Detail

Premature infants display increased noxious-evoked neuronal activity in the brain compared to healthy age-matched term-born infants.
MedLine Citation:
PMID:  20438855     Owner:  NLM     Status:  MEDLINE    
This study demonstrates that infants who are born prematurely and who have experienced at least 40days of intensive or special care have increased brain neuronal responses to noxious stimuli compared to healthy newborns at the same postmenstrual age. We have measured evoked potentials generated by noxious clinically-essential heel lances in infants born at term (8 infants; born 37-40weeks) and in infants born prematurely (7 infants; born 24-32weeks) who had reached the same postmenstrual age (mean age at time of heel lance 39.2+/-1.2weeks). These noxious-evoked potentials are clearly distinguishable from shorter latency potentials evoked by non-noxious tactile sensory stimulation. While the shorter latency touch potentials are not dependent on the age of the infant at birth, the noxious-evoked potentials are significantly larger in prematurely-born infants. This enhancement is not associated with specific brain lesions but reflects a functional change in pain processing in the brain that is likely to underlie previously reported changes in pain sensitivity in older ex-preterm children. Our ability to quantify and measure experience-dependent changes in infant cortical pain processing will allow us to develop a more rational approach to pain management in neonatal intensive care.
Rebeccah Slater; Lorenzo Fabrizi; Alan Worley; Judith Meek; Stewart Boyd; Maria Fitzgerald
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Publication Detail:
Type:  Journal Article     Date:  2010-05-08
Journal Detail:
Title:  NeuroImage     Volume:  52     ISSN:  1095-9572     ISO Abbreviation:  Neuroimage     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-10-15     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9215515     Medline TA:  Neuroimage     Country:  United States    
Other Details:
Languages:  eng     Pagination:  583-9     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Brain / physiopathology*
Evoked Potentials
Heel / physiopathology
Infant, Newborn
Infant, Premature / physiology*
Intensive Care
Pain / physiopathology*
Physical Stimulation
Principal Component Analysis
Signal Processing, Computer-Assisted
Time Factors
Touch Perception / physiology
Grant Support
G0502146//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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