Document Detail

Premature fusion of the proximal humeral epiphyses in thalassemia.
MedLine Citation:
PMID:  6600336     Owner:  NLM     Status:  MEDLINE    
Premature fusion of the proximal humeral epiphyses with varus deformity is a common and characteristic radiologic finding in thalassemia anemia. A review of 17 cases with bilateral and one case with unilateral involvement, coupled with known anatomic and mechanical factors, suggested an explanation for this phenomenon. Hypertrophied marrow will thin the trabeculae and cortex, perforate the cortex through normal fenestrations, and proliferate subperiosteally. Normal force vectors result in medial humeral compression and ultimately premature fusion.
J P Lawson; R C Ablow; H A Pearson
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  140     ISSN:  0361-803X     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2008-02-15    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Transfusion
Bone Marrow / physiology
Epiphyses / physiopathology,  radiography*
Humerus / physiopathology,  radiography*
Thalassemia / physiopathology*,  therapy
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