| Premature epiphyseal fusions in beta thalassaemia. | |
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MedLine Citation:
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PMID: 20306975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thalassemia patients are now living longer due to better transfusion methods and diagnostic awareness. To see whether this longevity is associated with orthopaedic disability, especially physeal growth defects, we examined 105 patients aged between 5-25 years for evidence of clinically detectable premature epiphyseal fusions (PEF). Ours is a center focussed on transfusion dependent beta thalassemia (TDBT) patient management, and so detailed transfusion records related to age at first transfusion, regularity of transfusions and pre-transfusional haemoglobin (Hb) levels were available. Five (4.7%) patients had deformities or limb length discrepancies, which lead to the detection of PEF. All patients with PEF had pre transfusion haemoglobin levels of less than 8 gm/dL. On comparing with the literature, we found that the prevalence of clinically detectable PEF in TDBT patients has decreased with better blood transfusion regimes. Though the pathogenesis of PEF is yet to be conclusively established, it is apparent that better control of the disease to maintain pre-transfusional haemoglobin levels consistently above 8 gm/dL in the first decade, can decrease the occurrence of PEF. |
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Authors:
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Praveen L Basanagoudar; Shivinder S Gill; Mandeep S Dhillon; Ram K Marwaha |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta orthopaedica Belgica Volume: 76 ISSN: 0001-6462 ISO Abbreviation: Acta Orthop Belg Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-23 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985165R Medline TA: Acta Orthop Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: IM |
Affiliation:
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Post Graduate Institute of Medical Education and Research, Chandigarh, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Blood Transfusion Bone Diseases, Developmental / etiology Child Child, Preschool Epiphyses / physiopathology* Female Hemoglobins / analysis Humans Joint Deformities, Acquired / etiology, radiography Male Young Adult beta-Thalassemia / blood, complications, physiopathology*, therapy |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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