Document Detail

Premature epiphyseal fusions in beta thalassaemia.
MedLine Citation:
PMID:  20306975     Owner:  NLM     Status:  MEDLINE    
Thalassemia patients are now living longer due to better transfusion methods and diagnostic awareness. To see whether this longevity is associated with orthopaedic disability, especially physeal growth defects, we examined 105 patients aged between 5-25 years for evidence of clinically detectable premature epiphyseal fusions (PEF). Ours is a center focussed on transfusion dependent beta thalassemia (TDBT) patient management, and so detailed transfusion records related to age at first transfusion, regularity of transfusions and pre-transfusional haemoglobin (Hb) levels were available. Five (4.7%) patients had deformities or limb length discrepancies, which lead to the detection of PEF. All patients with PEF had pre transfusion haemoglobin levels of less than 8 gm/dL. On comparing with the literature, we found that the prevalence of clinically detectable PEF in TDBT patients has decreased with better blood transfusion regimes. Though the pathogenesis of PEF is yet to be conclusively established, it is apparent that better control of the disease to maintain pre-transfusional haemoglobin levels consistently above 8 gm/dL in the first decade, can decrease the occurrence of PEF.
Praveen L Basanagoudar; Shivinder S Gill; Mandeep S Dhillon; Ram K Marwaha
Related Documents :
12956005 - Levels of malaria specific immunoglobulin g in nigerian sickle cell disease patients wi...
8042135 - Preanesthesia transfusion and sickle cell anemia patients: case report and controversies.
12022425 - Clinico-haematological profile of pure red cell aplasia in children.
20185605 - Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated...
2299975 - Rocky mountain spotted fever. a clinical review based on 48 confirmed cases, 1943-1986.
11007085 - Photography of severe laryngeal obstruction.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta orthopaedica Belgica     Volume:  76     ISSN:  0001-6462     ISO Abbreviation:  Acta Orthop Belg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985165R     Medline TA:  Acta Orthop Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Transfusion
Bone Diseases, Developmental / etiology
Child, Preschool
Epiphyses / physiopathology*
Hemoglobins / analysis
Joint Deformities, Acquired / etiology,  radiography
Young Adult
beta-Thalassemia / blood,  complications,  physiopathology*,  therapy
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Application guidelines for dynamic knee joint analysis with a dual fluoroscopic imaging system.
Next Document:  A modified Weaver-Dunn procedure without need for internal fixation.