Document Detail


Premature epiphyseal fusions in beta thalassaemia.
MedLine Citation:
PMID:  20306975     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thalassemia patients are now living longer due to better transfusion methods and diagnostic awareness. To see whether this longevity is associated with orthopaedic disability, especially physeal growth defects, we examined 105 patients aged between 5-25 years for evidence of clinically detectable premature epiphyseal fusions (PEF). Ours is a center focussed on transfusion dependent beta thalassemia (TDBT) patient management, and so detailed transfusion records related to age at first transfusion, regularity of transfusions and pre-transfusional haemoglobin (Hb) levels were available. Five (4.7%) patients had deformities or limb length discrepancies, which lead to the detection of PEF. All patients with PEF had pre transfusion haemoglobin levels of less than 8 gm/dL. On comparing with the literature, we found that the prevalence of clinically detectable PEF in TDBT patients has decreased with better blood transfusion regimes. Though the pathogenesis of PEF is yet to be conclusively established, it is apparent that better control of the disease to maintain pre-transfusional haemoglobin levels consistently above 8 gm/dL in the first decade, can decrease the occurrence of PEF.
Authors:
Praveen L Basanagoudar; Shivinder S Gill; Mandeep S Dhillon; Ram K Marwaha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta orthopaedica Belgica     Volume:  76     ISSN:  0001-6462     ISO Abbreviation:  Acta Orthop Belg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-03-23     Completed Date:  2010-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985165R     Medline TA:  Acta Orthop Belg     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  114-9     Citation Subset:  IM    
Affiliation:
Post Graduate Institute of Medical Education and Research, Chandigarh, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Blood Transfusion
Bone Diseases, Developmental / etiology
Child
Child, Preschool
Epiphyses / physiopathology*
Female
Hemoglobins / analysis
Humans
Joint Deformities, Acquired / etiology,  radiography
Male
Young Adult
beta-Thalassemia / blood,  complications,  physiopathology*,  therapy
Chemical
Reg. No./Substance:
0/Hemoglobins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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