| Premature coronary artery atherosclerosis in a patient with Prader-Willi syndrome. | |
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MedLine Citation:
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PMID: 3688025 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 26-year old white male with Prader-Willi syndrome (PWS) and non-insulin-dependent diabetes mellitus presented with asymptomatic bilateral lower limb swelling. An electrocardiogram was consistent with an inferior wall myocardial infarction of unknown age and a graded exercise test using the Bruce protocol was consistent with inferolateral ischemia. Subsequent cardiac catheterization showed severe, inoperable, three-vessel coronary artery disease. Atherosclerotic coronary artery disease in PWS has been documented only once in the literature, and then only postmortem. This case provides further (and for the first time, premortem) documentation that premature atherosclerotic coronary artery disease may play an important but presently unrecognized role in the morbidity and mortality in PWS. |
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Authors:
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A S Lamb; W M Johnson |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of medical genetics Volume: 28 ISSN: 0148-7299 ISO Abbreviation: Am. J. Med. Genet. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-01-21 Completed Date: 1988-01-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7708900 Medline TA: Am J Med Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 873-80 Citation Subset: IM |
Affiliation:
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Department of Medicine, Dwight David Eisenhower, Army Medical Center, Fort Gordon, Georgia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Coronary Artery Disease / pathology* Coronary Vessels / pathology Humans Male Prader-Willi Syndrome / pathology* Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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