Document Detail

Premature compared with late onset of coronary artery disease: young patients show a severe defect in fibrinolytic response to venous occlusion.
MedLine Citation:
PMID:  17287634     Owner:  NLM     Status:  MEDLINE    
Inflammatory processes play a role in the onset of acute cardiovascular events associated with activation of the coagulation system whereas the fibrinolytic system may prevent local thrombus formation. We compared 25 patients with premature coronary artery disease (CAD) (first ST-elevation myocardial infarction, < 55 years old) with 25 sex-matched patients older than 55 years at their first myocardial infarction. Six months after the acute event, patients with late onset of CAD showed a significantly higher increase of tissue-type plasminogen activator activity during venous occlusion compared with patients with premature CAD (P < 0.005). Prothrombin fragment 1+2 was higher in patients with late-onset CAD (P < 0.05), whereas the inflammatory markers C-reactive protein and soluble intercellular cell adhesion molecule-1 were not different in both groups. A multivariate analysis including cardiovascular risk factors showed that the tissue-type plasminogen activator response to venous occlusion was independently associated with patient age at onset of first ST-elevation myocardial infarction. Although in our series high age was associated with a prothrombotic state, a high fibrinolytic capacity might have some beneficial effect and contribute to a delayed onset of adverse cardiovascular events in these patients.
Walter Stefan Speidl; Mariam Nikfardjam; Alexander Niessner; Nelli Jordanova; Gerlinde Zorn; Gerald Maurer; Wolfgang Schreiber; Johann Wojta; Kurt Huber
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  18     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-08     Completed Date:  2007-05-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
Department of Internal Medicine II, Medical University of Vienna and the Ludwig Boltzman Foundation for Cardiovascular Resarch, Vienna, Austria.
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MeSH Terms
Age of Onset
Biological Markers / blood
Coronary Artery Disease / blood,  etiology*
Inflammation / blood
Middle Aged
Myocardial Infarction
Thrombophilia / blood
Tissue Plasminogen Activator / blood*
Venous Thrombosis / blood*
Reg. No./Substance:
0/Biological Markers; EC Plasminogen Activator

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