| Premature cardiac contractions produced efficiently by external high-intensity focused ultrasound. | |
| | |
MedLine Citation:
|
PMID: 21684453 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Exposure of myocardium to a mechanical impact may produce premature ventricular contractions (PVCs). High-intensity focused ultrasound was reported to generate PVCs, while microbubbles at the target increased absorption, thus, promoting energy localization and decreased PVC threshold. The objective was to investigate the benefit of a two-stage ultrasonic transmission: (1) asymmetric mostly negative waveform at the focus (microbubbles generation) and (2) asymmetric mostly positive waveform at the microbubbles (impact generation). Optimization of transmission parameters was performed by measuring passive cavitation and attenuation. In vivo intact rat studies were performed while measuring electrocardiograph (ECG) and blood pressure. Most PVCs with blood injection were created while applying 3.06 MPa peak negative pressure during 1 ms, followed by 5.1 MPa peak positive pressure during 50 ms. Increasing the second stage from 5 ms to 50 ms increased the occurrence of PVCs. This study demonstrates that creation of localized microbubble population at the target promotes generation of PVCs without the need to inject contrast agents. |
| | |
Authors:
|
Anat Hersch; Dan Adam |
Related Documents
:
|
8368663 - Venous insufficiency: a late sequelae of four-compartment fasciotomy in the lower extre... 2494863 - Venous pressure measurements in vein of galen aneurysms. 9328883 - Estimating phonation threshold pressure. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ultrasound in medicine & biology Volume: 37 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-06-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 1101-10 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Technion, Israel Institute of Technology, Technion City, Haifa, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiview Fusion 3-d Echocardiography: Improving the Information and Quality of Real-Time 3-D Echoca...
Next Document: An Adaptive Spectral Estimation Technique to Detect Cavitation in HIFU With High Spatial Resolution.