Document Detail

Premature cardiac contractions produced efficiently by external high-intensity focused ultrasound.
MedLine Citation:
PMID:  21684453     Owner:  NLM     Status:  In-Data-Review    
Exposure of myocardium to a mechanical impact may produce premature ventricular contractions (PVCs). High-intensity focused ultrasound was reported to generate PVCs, while microbubbles at the target increased absorption, thus, promoting energy localization and decreased PVC threshold. The objective was to investigate the benefit of a two-stage ultrasonic transmission: (1) asymmetric mostly negative waveform at the focus (microbubbles generation) and (2) asymmetric mostly positive waveform at the microbubbles (impact generation). Optimization of transmission parameters was performed by measuring passive cavitation and attenuation. In vivo intact rat studies were performed while measuring electrocardiograph (ECG) and blood pressure. Most PVCs with blood injection were created while applying 3.06 MPa peak negative pressure during 1 ms, followed by 5.1 MPa peak positive pressure during 50 ms. Increasing the second stage from 5 ms to 50 ms increased the occurrence of PVCs. This study demonstrates that creation of localized microbubble population at the target promotes generation of PVCs without the need to inject contrast agents.
Anat Hersch; Dan Adam
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  37     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1101-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Technion, Israel Institute of Technology, Technion City, Haifa, Israel.
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