Document Detail

Premarital screening of hemoglobinopathies: a pilot study in Turkey.
MedLine Citation:
PMID:  8666411     Owner:  NLM     Status:  MEDLINE    
To identify premarital couples who are carriers for hemoglobinopathies, a screening study was conducted in one of the southern cities of Turkey. For 2,113 couples, total blood count, Hb A2 and Hb F levels were determined and hemoglobin electrophoresis was performed. The frequency of Hb S was 4.6% and beta thalassemia 2.3%. In 35 of 2,113 prospective families, both partners were found to be carriers. During the 4-year follow-up period, prenatal diagnosis was sought in 10 pregnancies of these at-risk families. This study indicated that premarital screening is a very useful tool for detecting carrier couples. The immediate beneficial effect of this study was the application of prenatal hemoglobinopathy diagnosis from the first pregnancy.
C Altay; E Yilgör; S Beksac; A Gürgey
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human heredity     Volume:  46     ISSN:  0001-5652     ISO Abbreviation:  Hum. Hered.     Publication Date:    1996 Mar-Apr
Date Detail:
Created Date:  1996-08-05     Completed Date:  1996-08-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  112-4     Citation Subset:  IM    
Department of Pediatric Hematology, Ihsan Dogramaci Children's Hospital, Ankara, Turkey.
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MeSH Terms
Blood Cell Count
Follow-Up Studies
Genetic Testing*
Hemoglobinopathies / blood,  diagnosis*
Hemoglobins / classification
Heterozygote Detection
Pilot Projects
Premarital Examinations*
Prenatal Diagnosis
Reg. No./Substance:
Comment In:
Hum Hered. 1996 Nov-Dec;46(6):342-3   [PMID:  8956032 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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