Document Detail

Premarital screening of beta-thalassemia trait in the province of Denizli, Turkey.
MedLine Citation:
PMID:  11111119     Owner:  NLM     Status:  MEDLINE    
A premarital screening program aiming at reducing the incidence of thalassemia major was started under the auspices of the Regional Health Administration in 1995 in the city of Denizli in the Aegean region of Turkey. In this report we assessed the 4-year results of the screening program. All couples who applied for marriage procedures were screened for beta-thalassemia trait by automatic red cell indices and Hb A(2) determination. The couples at risk were counseled and offered prenatal diagnosis and termination of pregnancy in case of an affected fetus. From October 1995 to August 1999, a total of 19,804 subjects (9,902 couples) were recruited for this study. The prevalence of beta-thalassemia trait with increased Hb A(2) was found to be 2.6% (514/19,804). In addition to the thalassemia trait, 22 patients (0.11%) had sickle trait. In 15 of the 9,902 couples, both partners were found to be carriers of the beta-thalassemia trait. After genetic counseling, 2 of the 15 planned carrier marriages were canceled. Seven couples declared that they do not want to have a child at present. Prenatal diagnosis was sought by 6 couples. One fetus was found to be normal, 4 had thalassemia minor and 1 had thalassemia major; this pregnancy was terminated by elective abortion. This study indicated that premarital screening is a very useful tool for detecting carrier couples and an effective way of controlling thalassemia major.
A Keskin; T Türk; A Polat; H Koyuncu; B Saracoglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta haematologica     Volume:  104     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-12-26     Completed Date:  2001-01-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  31-3     Citation Subset:  IM    
Copyright Information:
Copyright 2000 S. Karger AG, Basel
Faculty of Medicine, Pamukkale University, Denizli, Turkey.
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MeSH Terms
Abortion, Induced
Decision Making
Family Health
Genetic Counseling / methods
Hemoglobin A2 / metabolism
Mass Screening
Premarital Examinations*
Prenatal Diagnosis
Sickle Cell Trait / complications
Turkey / epidemiology
beta-Thalassemia / epidemiology*,  genetics,  prevention & control*
Reg. No./Substance:
9034-53-1/Hemoglobin A2
Comment In:
Acta Haematol. 2001;105(4):252   [PMID:  11528103 ]

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