Document Detail

Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis.
MedLine Citation:
PMID:  20657272     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To ascertain whether Premarin improves spinal cord injury outcomes in male rats by stimulating both angiogenesis and neurogenesis. DESIGN: Chi Mei Medical Center research laboratory. SUBJECTS: Male Sprague-Dawley rats 240-258 g. INTERVENTIONS: Anesthetized rats, after the onset of spinal cord injury, were divided into two groups and given the vehicle solution (1 mL/kg of body weight) or Premarin (1 mg/kg of body weight). Saline or Premarin solutions were administered intravenously and immediately after spinal cord injury. MEASUREMENTS AND MAIN RESULTS: Premarin (an estrogen sulfate) causes attenuation of spinal cord injury-induced spinal cord infarction and hind limb locomotor dysfunction. Spinal cord injury-induced apoptosis as well as activated inflammation was also significantly Premarin-reduced. In injured spinal cord, angiogenesis, neurogenesis, and production of an antiinflammatory cytokine were all Premarin therapy-promoted. CONCLUSIONS: Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats.
Sheng-Hsien Chen; Chao-Hung Yeh; Mike Yang-Sheng Lin; Chieh-Yi Kang; Chin-Chen Chu; Fong-Ming Chang; Jhi-Joung Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  38     ISSN:  1530-0293     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-21     Completed Date:  2010-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2043-51     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan.
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MeSH Terms
Apoptosis / drug effects
DNA Nucleotidylexotransferase / drug effects
Estrogens / therapeutic use*
Estrogens, Conjugated (USP) / therapeutic use*
Inflammation / drug therapy
Interleukin-10 / blood
Neovascularization, Physiologic / drug effects*
Neurogenesis / drug effects*
Rats, Sprague-Dawley
Spinal Cord Injuries / drug therapy*,  physiopathology
Tumor Necrosis Factor-alpha / blood
Reg. No./Substance:
0/Estrogens; 0/Estrogens, Conjugated (USP); 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; EC Nucleotidylexotransferase
Comment In:
Crit Care Med. 2010 Oct;38(10):2078-9   [PMID:  20856002 ]

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