| Premarin improves outcomes of spinal cord injury in male rats through stimulating both angiogenesis and neurogenesis. | |
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MedLine Citation:
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PMID: 20657272 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To ascertain whether Premarin improves spinal cord injury outcomes in male rats by stimulating both angiogenesis and neurogenesis. DESIGN: Chi Mei Medical Center research laboratory. SUBJECTS: Male Sprague-Dawley rats 240-258 g. INTERVENTIONS: Anesthetized rats, after the onset of spinal cord injury, were divided into two groups and given the vehicle solution (1 mL/kg of body weight) or Premarin (1 mg/kg of body weight). Saline or Premarin solutions were administered intravenously and immediately after spinal cord injury. MEASUREMENTS AND MAIN RESULTS: Premarin (an estrogen sulfate) causes attenuation of spinal cord injury-induced spinal cord infarction and hind limb locomotor dysfunction. Spinal cord injury-induced apoptosis as well as activated inflammation was also significantly Premarin-reduced. In injured spinal cord, angiogenesis, neurogenesis, and production of an antiinflammatory cytokine were all Premarin therapy-promoted. CONCLUSIONS: Our results indicate that Premarin therapy may protect against spinal cord apoptosis after spinal cord injury through mechanisms stimulating both angiogenesis and neurogenesis in male rats. |
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Authors:
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Sheng-Hsien Chen; Chao-Hung Yeh; Mike Yang-Sheng Lin; Chieh-Yi Kang; Chin-Chen Chu; Fong-Ming Chang; Jhi-Joung Wang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Critical care medicine Volume: 38 ISSN: 1530-0293 ISO Abbreviation: Crit. Care Med. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-21 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0355501 Medline TA: Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 2043-51 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan, Taiwan. 891201@mail.chimei.org.tw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects DNA Nucleotidylexotransferase / drug effects Estrogens / therapeutic use* Estrogens, Conjugated (USP) / therapeutic use* Inflammation / drug therapy Interleukin-10 / blood Male Neovascularization, Physiologic / drug effects* Neurogenesis / drug effects* Rats Rats, Sprague-Dawley Spinal Cord Injuries / drug therapy*, physiopathology Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Estrogens, Conjugated (USP); 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; EC 2.7.7.31/DNA Nucleotidylexotransferase |
| Comments/Corrections | |
Comment In:
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Crit Care Med. 2010 Oct;38(10):2078-9
[PMID:
20856002
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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