Document Detail

Premalignant nature of oral lichen planus. A retrospective study of 550 oral lichen planus patients from south-eastern Spain.
MedLine Citation:
PMID:  19362039     Owner:  NLM     Status:  MEDLINE    
The most important complication of oral lichen planus (OLP) is the development of squamous cell carcinoma (SCC)--this being an association that remains subject to controversy. This study aims to examine the incidence and clinical presentation of oral malignancies associated with OLP. A retrospective study was made of 550 patients diagnosed with OLP according to the criteria of the World Health Organization, in the period between 1991 and 2007, in south-eastern Spain 128 males (23.3%) and 422 females (76.7%). A clinical protocol was applied in all cases (sociodemographic data, habits and hepatitis C markers), with histological confirmation of the disease. Five of the 550 patients (0.9%) developed SCC. The mean duration of follow-up was 24+/-20.83 months. The tongue was the most common location. The exact incidence of malignant transformation of OLP is difficult to establish, due to the possible contribution of external risk factors that may be of relevance in oral malignancy.
A Bermejo-Fenoll; M Sanchez-Siles; P López-Jornet; F Camacho-Alonso; N Salazar-Sanchez
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2009-04-09
Journal Detail:
Title:  Oral oncology     Volume:  45     ISSN:  1879-0593     ISO Abbreviation:  Oral Oncol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2010-12-28     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  9709118     Medline TA:  Oral Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  e54-6     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / pathology*
Cell Transformation, Neoplastic
Disease Progression
Lichen Planus, Oral / pathology*
Middle Aged
Mouth Neoplasms / pathology*
Precancerous Conditions / pathology*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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