Document Detail

Premalignant lesions of the prostate.
MedLine Citation:
PMID:  3051237     Owner:  NLM     Status:  MEDLINE    
Two putative premalignant lesions of the prostate have been identified. Prostatic intraepithelial neoplasia (PIN) is characterized by proliferation and anaplasia of cells lining ducts and acini. Atypical adenomatous hyperplasia (AAH) consists of a localized proliferation of small round glands without cytologic atypia. PIN and AAH may be confused with well-differentiated carcinoma as well as florid hyperplasia, basal cell hyperplasia, transitional metaplasia, seminal vesicular epithelium, and atypia due to inflammation, infarction, and radiation. These premalignant lesions appear to have a high predictive value for carcinoma, and their presence on prostatic biopsy warrants further search for concurrent invasive adenocarcinoma. The use of strict morphologic criteria and uniform nomenclature will ensure standardization in the diagnosis of premalignant lesions of the prostate.
D G Bostwick
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in diagnostic pathology     Volume:  5     ISSN:  0740-2570     ISO Abbreviation:  Semin Diagn Pathol     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-11-22     Completed Date:  1988-11-22     Revised Date:  2007-05-16    
Medline Journal Info:
Nlm Unique ID:  8502262     Medline TA:  Semin Diagn Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-53     Citation Subset:  IM    
Department of Pathology, University of Maryland School of Medicine, Mercy Medical Center, Baltimore 21202.
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MeSH Terms
Anaplasia / pathology
Hyperplasia / pathology
Precancerous Conditions / classification,  pathology*
Prostate / pathology
Prostatic Neoplasms / pathology*

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