Document Detail


Premalignant lesions of the larynx. A follow-up study.
MedLine Citation:
PMID:  2929313     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The object of this investigation was to evaluate in the long-term the risk of malignancy occurring in the larynx of patients with dysplasia in the laryngeal epithelium. Over an 8-year period, 1974-82, 170 patients underwent microlaryngoscopic examination of the larynx including biopsy, showing hyperplasia and/or keratosis with or without dysplasia in the laryngeal epithelium. Of these, 147 patients were examined, on an average, 5 years and 4 months later. All histological specimens were reviewed by the same pathologist. Of the patients initially showing mild dysplasia, 7.8% developed aggravation while 55.6% of the patients displaying moderate dysplasia had developed severe dysplasia or carcinoma. 93.2% were smokers. It is concluded that all patients with atypia in the laryngeal epithelium should be observed at regular intervals, but special attention should be given to patients showing moderate dysplasia or worse.
Authors:
P E Højslet; V M Nielsen; D Palvio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta oto-laryngologica     Volume:  107     ISSN:  0001-6489     ISO Abbreviation:  Acta Otolaryngol.     Publication Date:    1989 Jan-Feb
Date Detail:
Created Date:  1989-05-10     Completed Date:  1989-05-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370354     Medline TA:  Acta Otolaryngol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  150-5     Citation Subset:  IM    
Affiliation:
ENT Department, Aalborg Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biopsy
Female
Humans
Laryngeal Neoplasms / epidemiology,  pathology*
Male
Middle Aged
Precancerous Conditions / pathology*
Risk Factors

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