Document Detail


Premalignant circumscribed palmar hypokeratosis: a new form of circumscribed palmar hypokeratosis? Case report and literature review.
MedLine Citation:
PMID:  19955702     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Circumscribed palmoplantar hypokeratosis (CPH) is a recently described dermatosis of unknown origin, of which 46 cases have been published so far. CPH affects predominantly adult women. It presents clinically with a sharply circumscribed annular erythematous depressed plaque rimmed by a slightly hyperkeratotic border, localized usually over the thenar or hypothenar eminences of the palm, less commonly on the soles. Histopathologically, it is characterized by an abrupt decrease in the horny layer thickness, forming a sharp stair between normal and involved skin. We report herein a new patient with CPH who presented an associated aspect of actinic keratosis, a hitherto unreported finding. This case suggests that CPH can undergo malignant transformation, probably as a result of actinic damage. On this occasion, a complete literature review of CPH is presented.
Authors:
J Kanitakis; V Lora; B Balme; J Roby
Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-12-02
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  220     ISSN:  1421-9832     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-05     Completed Date:  2010-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  143-6     Citation Subset:  IM    
Affiliation:
Laboratory of Dermatopathology, Edouard Herriot Hospital, Lyon, France. jean.kanitakis@univ-lyon1.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Cell Transformation, Neoplastic / pathology*
Diagnosis, Differential
Female
Humans
Keratoderma, Palmoplantar / pathology*
Keratosis, Actinic / pathology*
Male
Middle Aged
Skin Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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