| Preload-adjusted maximal power of right ventricle: contribution of end-systolic P-V relation intercept. | |
| | |
MedLine Citation:
|
PMID: 12234823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To assess whether preload-adjusted maximal power (PAMP), which is calculated as W(max)/V (where W(max) is maximal power and V(ed) is end-diastolic volume with beta = 2) is an index of right ventricular (RV) contractility, we measured RV pressure (P) and volume (V) and pulmonary artery pressure and flow in 10 dogs at baseline and after inotropic stimulation. PAMP was derived from steady-state data, whereas the slope (E(es)) and intercept (V(d)) of the end-systolic P-V relationship were derived from data obtained during vena caval occlusion. Inotropic stimulation increased E(es) (from 0.96 +/- 0.25 to 1.62 +/- 0.28 mmHg/ml; P < 0.001) and V(d) (from -3.0 +/- 17.2 to 12.4 +/- 10.8 ml; P < 0.05) but not PAMP (from 0.24 +/- 0.10 to 0.36 +/- 0.22 mW/ml(2); P = 0.09). We found a strong relationship between the optimal beta-factor for preload adjustment and V(d). A corrected PAMP, PAMP(c) = W(max)/(V(ed) - V(d))(2), which incorporated the V(d) dependency, was sensitive to the inotropic changes (from 0.23 +/- 0.12 to 0.54 +/- 0.17 mW/ml(2); P < 0.001) with a good correlation with E(es) (r = 0.88; P < 0.001). |
| | |
Authors:
|
Patrick Segers; H Alex Leather; Pascal Verdonck; Yuan-Yuan Sun; Patrick F Wouters |
Related Documents
:
|
8850643 - Distributed mechanics of the canine right ventricle: effects of varying preload. 6846553 - Filling and arterial pressures as determinants of rv stroke volume in the sheep fetus. 3396963 - Reproducibility of ambulatory oesophageal ph monitoring. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2002-06-13 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 283 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2002 Oct |
Date Detail:
|
Created Date: 2002-09-17 Completed Date: 2002-10-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H1681-7 Citation Subset: IM |
Affiliation:
|
Hydraulics Laboratory, Institute of Biomedical Technology, Ghent University, Belgium. patrick.segers@rug.ac.be |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / physiology Cardiac Volume / physiology Dogs Models, Cardiovascular Pulmonary Wedge Pressure / physiology Stroke Volume / physiology Systole / physiology* Ventricular Function, Right / physiology* Ventricular Pressure / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Next Document: Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange.