| Preliminary study of positron emission tomography/computed tomography and plasma osteopontin levels in patients with asbestos-related pleural disease. | |
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MedLine Citation:
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PMID: 20661695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of this study was to compare the results of semiquantitative analysis by(18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) with plasma osteopontin levels in the same asbestos-related pleural disease population. MATERIALS AND METHODS: A total of 17 patients with asbestos-related pleural disease were prospectively recruited. They underwent PET/CT, and plasma osteopontin levels were measured. The maximum standardized uptake value (SUVmax) was determined from the most active pleural lesion in each patient. RESULTS: Malignant pleural mesothelioma (MPM) was histologically proven in 6 patients, and 11 patients had proven benign asbestos-related pleural diseases (7 pleural plaques, 4 asbestos pleurisy). Significant differences in SUVmax were found between patients with MPM and those with asbestos pleurisy (P = 0.031) and between patients with MPM and those with pleural plaques (P = 0.012). A significant difference was found in the plasma osteopontin levels between patients with asbestos pleurisy and patients with pleural plaques (Bonferroni correction, P = 0.024). The SUVmax in patients with benign asbestos-related diseases was statistically positively correlated with plasma osteopontin in the same group (Spearman's r = 0.75, P < 0.05). CONCLUSION: PET/CT might be more helpful than plasma osteopontin for distinguishing benign asbestos-related pleural diseases from MPM, and the SUVmax in benign asbestos-related pleural diseases may reflect changes in pleural inflammation. |
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Authors:
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Seiji Kurata; Masatoshi Ishibashi; Koichi Azuma; Hayato Kaida; Shinzo Takamori; Kiminori Fujimoto; Maiko Kobayashi; Yasumitsu Hirose; Hisamichi Aizawa; Naofumi Hayabuchi |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-27 |
Journal Detail:
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Title: Japanese journal of radiology Volume: 28 ISSN: 1867-108X ISO Abbreviation: Jpn J Radiol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-27 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101490689 Medline TA: Jpn J Radiol Country: Japan |
Other Details:
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Languages: eng Pagination: 446-52 Citation Subset: IM |
Affiliation:
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Division of Nuclear Medicine and PET Center, Department of Radiology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. skur@med.kurume-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Asbestos / blood, toxicity* Diagnosis, Differential Female Fluorodeoxyglucose F18 / diagnostic use Humans Imaging, Three-Dimensional / methods Male Mesothelioma / blood, etiology, radionuclide imaging* Middle Aged Osteopontin / blood* Pleura / radiography, radionuclide imaging Pleural Diseases / blood, etiology, radionuclide imaging* Pleural Neoplasms / blood, radionuclide imaging Pleurisy / blood, radionuclide imaging Positron-Emission Tomography / methods* Prospective Studies Radiopharmaceuticals / diagnostic use Tomography, Spiral Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 106441-73-0/Osteopontin; 1332-21-4/Asbestos; 63503-12-8/Fluorodeoxyglucose F18 |
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