Document Detail


Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage.
MedLine Citation:
PMID:  16621619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To demonstrate the ability of a novel radiographic technique, Diffraction Enhanced Radiographic Imaging (DEI), to render high contrast images of canine knee joints for identification of cartilage lesions in situ. METHODS: DEI was carried out at the X-15A beamline at Brookhaven National Laboratory on intact canine knee joints with varying levels of cartilage damage. Two independent observers graded the DE images for lesions and these grades were correlated to the gross morphological grade. RESULTS: The correlation of gross visual grades with DEI grades for the 18 canine knee joints as determined by observer 1 (r2 = 0.8856, P = 0.001) and observer 2 (r2 = 0.8818, P = 0.001) was high. The overall weighted kappa value for inter-observer agreement was 0.93, thus considered high agreement. CONCLUSION: The present study is the first study for the efficacy of DEI for cartilage lesions in an animal joint, from very early signs through erosion down to subchondral bone, representing the spectrum of cartilage changes occurring in human osteoarthritis (OA). Here we show that DEI allows the visualization of cartilage lesions in intact canine knee joints with good accuracy. Hence, DEI may be applicable for following joint degeneration in animal models of OA.
Authors:
C Muehleman; J Li; Z Zhong
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-04-18
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  14     ISSN:  1063-4584     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-07     Completed Date:  2007-04-04     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  882-8     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Rush University Medical Center, Anatomy and Biochemistry, Cohn building, Room 524, 1735 W Chicago, IL 60612, USA. carol_muehleman@rush.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Cartilage, Articular / pathology,  radiography*
Dogs
Models, Animal
Osteoarthritis, Knee / pathology,  radiography*
Radiographic Image Enhancement*
X-Ray Diffraction*
Grant Support
ID/Acronym/Agency:
R01 AR48292/AR/NIAMS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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