Document Detail


Preliminary study on the cytoarchitecture of the human parabrachial/Kölliker-fuse complex, with reference to sudden infant death syndrome and sudden intrauterine unexplained death.
MedLine Citation:
PMID:  15022077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The parabrachial/Kölliker-Fuse complex has been defined, in different animal species, to lie in the dorsolateral part of the pontine tegmentum and to be subdivided into three well-defined regions: the medial parabrachial nucleus, the lateral parabrachial nucleus, and the Kölliker-Fuse nucleus. Experimental studies have shown that the parabrachial/Kölliker-Fuse complex is involved in a variety of functional activities and above all plays an important role in respiratory modulation. In human brainstem, the cytoarchitecture and physiology of this complex have not yet been fully characterized. The aim of the present study was to examine fetal and infant human brainstems in order to define the precise morphology of the three nuclei of the parabrachial/Kölliker-Fuse complex, and to determine whether this nervous center shows morphologic alterations in sudden infant death syndrome (SIDS) and in sudden intrauterine unexplained death (SIUD). In serial sections of 31 brainstems of subjects aged from 32 gestational wk to 10 months of life, we studied, by morphologic and morphometric analyses, the cytoarchitecture and the extension of the three nuclei of the parabrachial/Kölliker-Fuse complex. All the morphometric parameters were very similar in SIUD and SIDS cases to those of the respective control group, as shown by the absence of significant statistical differences between the two fetus and infant groups. We observed that the features of both the lateral and the medial parabrachial nuclei are largely consistent with those reported in experimental studies. In contrast, the Kölliker-Fuse nucleus appears to be more developed in human beings than in other animal species, showing a greater extension and a more complex structure, as well as subdivision into two subnuclei (compactus and dissipatus).
Authors:
Anna Maria Lavezzi; Giulia Ottaviani; Gianmario Ballabio; Lino Rossi; Luigi Matturri
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-03-17
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  7     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2004 Mar-Apr
Date Detail:
Created Date:  2004-05-31     Completed Date:  2004-12-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  171-9     Citation Subset:  IM    
Affiliation:
Institute of Pathology, University of Milan, Via della Commenda 19, 20122, Milan, Italy. anna.lavezzi@unimi.it
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MeSH Terms
Descriptor/Qualifier:
Female
Fetus
Humans
Infant, Newborn
Male
Neurons / cytology*,  pathology
Pregnancy
Pregnancy Outcome
Respiratory Center / anatomy & histology*
Sudden Infant Death / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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