Document Detail

Preliminary studies with a live streptomycin-dependent Pasteurella multocida and Pasteurella haemolytica vaccine for the prevention of bovine pneumonic pasteurellosis.
MedLine Citation:
PMID:  3907804     Owner:  NLM     Status:  MEDLINE    
Twelve Pasteurella-free Holstein-Friesian calves were used in a study to test the efficacy of a live streptomycin-dependent Pasteurella multocida A:3 and streptomycin-dependent Pasteurella haemolytica A1 vaccine. The calves were inoculated intramuscularly twice at 14-day intervals with either the streptomycin-dependent vaccine, containing 1 X 10(6) colony forming units/mL P. multocida and 4 X 10(8) colony forming units/mL P. haemolytica, commercial bacterin, or phosphate buffered saline. Two weeks following the second vaccination, all calves were challenged by intranasal inoculation of 10(8) TCID50/4.0 mL infectious bovine rhinotracheitis virus followed three days later by intratracheal injection with 2.3 X 10(7) colony forming units/mL of a 16 hour culture of P. multocida A:3 and 2.6 X 10(8) colony forming units/mL of an 8 hour culture of P. haemolytica A1. Seven days after challenge with Pasteurella, calves were killed for collection of tissues at necropsy. Each calf was given a score based on macroscopic and microscopic lesions. The scores for the calves receiving live vaccines were significantly lower (p less than 0.025) than those for the controls. Also, the calves receiving live vaccines had a significant (p less than 0.05) increase in the level of serum antibody to P. haemolytica. The results of this preliminary study showed that the streptomycin-dependent vaccine offered better protection than the commercial bacterin against a virulent homologous challenge.
D M Catt; M M Chengappa; W L Kadel; C E Herren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of comparative medicine. Revue canadienne de médecine comparée     Volume:  49     ISSN:  0008-4050     ISO Abbreviation:  Can. J. Comp. Med.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-20     Completed Date:  1986-02-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0151747     Medline TA:  Can J Comp Med     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  IM    
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MeSH Terms
Antibodies, Bacterial / biosynthesis
Bacterial Vaccines / therapeutic use*
Cattle Diseases / prevention & control*
Pasteurella / drug effects,  immunology
Pasteurella Infections / prevention & control*,  veterinary*
Pasteurellosis, Pneumonic / prevention & control*
Streptomycin / pharmacology
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 57-92-1/Streptomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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