Document Detail

Preliminary studies of the mode of action of arildone, a novel antiviral agent.
MedLine Citation:
PMID:  224808     Owner:  NLM     Status:  MEDLINE    
Arildone (also known as Win 38020), a novel aryl diketone, inhibited replication of herpes simplex virus type 2 in tissue culture by interfering with an event that occurs prior to 6 h postinfection. The inhibition could be partially reversed by washing. Although the exact mechanism of action is unknown, neither viral deoxyribonucleic acid nor viral proteins were synthesized in the presence of arildone.
M F Kuhrt; M J Fancher; V Jasty; F Pancic; P E Came
Related Documents :
6203308 - Herpes simplex as a possibly occupational disease in dentists of the county of aarhus, ...
6257758 - Sensitive chemiluminescent enzyme-linked immunosorbent assay for quantification of huma...
1657508 - A virus-particle vaccine prepared from bovine mammillitis virus against herpes genitalis.
194538 - Generalized acute mucocutaneous herpes simplex type 2 with fatal outcome.
22003028 - Lack of correlation between virus barosensitivity and the presence of a viral envelope ...
9261348 - Nucleotide substitutions within u5 are critical for efficient reverse transcription of ...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  15     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  813-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antiviral Agents / pharmacology*
Centrifugation, Density Gradient
DNA / biosynthesis
DNA, Viral / biosynthesis
Ketones / pharmacology*
Kidney / drug effects,  metabolism
Plaque Assay
Protein Biosynthesis
RNA / biosynthesis
Simplexvirus / drug effects,  metabolism
Time Factors
Viral Proteins / biosynthesis
Virus Replication / drug effects
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; 0/Ketones; 0/Viral Proteins; 63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase in human cerebrospinal fluid.
Next Document:  Effect of 5-iodo-5'-amino-2',5'-dideoxyuridine on varicella-zoster virus in vitro.