Document Detail


Preliminary studies of the mode of action of arildone, a novel antiviral agent.
MedLine Citation:
PMID:  224808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arildone (also known as Win 38020), a novel aryl diketone, inhibited replication of herpes simplex virus type 2 in tissue culture by interfering with an event that occurs prior to 6 h postinfection. The inhibition could be partially reversed by washing. Although the exact mechanism of action is unknown, neither viral deoxyribonucleic acid nor viral proteins were synthesized in the presence of arildone.
Authors:
M F Kuhrt; M J Fancher; V Jasty; F Pancic; P E Came
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  15     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-10-26     Completed Date:  1979-10-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  813-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / pharmacology*
Centrifugation, Density Gradient
DNA / biosynthesis
DNA, Viral / biosynthesis
Haplorhini
Ketones / pharmacology*
Kidney / drug effects,  metabolism
Plaque Assay
Protein Biosynthesis
RNA / biosynthesis
Simplexvirus / drug effects,  metabolism
Time Factors
Viral Proteins / biosynthesis
Virus Replication / drug effects
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/DNA, Viral; 0/Ketones; 0/Viral Proteins; 63231-63-0/RNA; 9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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