Document Detail


Preliminary results of radiotherapy for primary intraocular non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  23343177     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract This study aims to retrospectively evaluate the efficacy of radiotherapy for primary intraocular non-Hodgkin's lymphoma (PIOL). Between May 1998 and October 2010, 22 immunocompetent patients (4 men, 18 women; median age 70 years; range 53-79 years) were diagnosed with PIOL. Magnetic resonance imaging showed no intracranial involvement in any patient. Patients received radiotherapy median total dose of 30 Gy (range 30-40 Gy). Three-year overall survival, progression-free survival and local control rates were 89% (95% confidence interval [CI]: 75, 103), 49% (95% CI: 24, 73) and 95% (95% CI: 86, 105) over a median of 36 months of observation, respectively. Twelve patients (55%) had intracranial relapse at a median of 28 months after initiation of radiotherapy. Visual acuity improved or was stable in 81% of treated eyes. The only grade ≥ 3 toxicity was cataract formation (5 patients). Radiotherapy without chemotherapy for PIOL achieved high local control rates with acceptable toxicities.
Authors:
Ryuji Mikami; Hidetsugu Nakayama; Hiroshi Goto; Keisuke Kimura; Sachika Nogi; Mitsuru Okubo; Naoto Kanesaka; Shinji Sugahara; Koichi Tokuuye
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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