Document Detail

Preliminary results of left heart bypass in pigs using a heparin-coated centrifugal pump.
MedLine Citation:
PMID:  1863146     Owner:  NLM     Status:  MEDLINE    
To assess the feasibility of left ventricular assist without systemic heparinization, we used a commercially available (Sarns 3M) centrifugal pump with tubing set and cannulas, all internally precoated for the purpose of this study with heparin, to bypass the left ventricle in 12 pigs for periods of either 1 or 3 hours. There was no significant activation of clotting and there was no sign of generalized embolization. However, on postmortem studies, 5 kidneys out of 22 examined showed signs of minimal thromboembolism. This experiment shows that artificial left ventricular assist, free of systemic heparinization but using heparin precoating, is feasible and safe, at least for a short period of time.
C Campanella; E Cameron; C Sinclair; V L Feilberg; C Hider; S Prasad; F Boulton; D Lamb
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  52     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1991-09-03     Completed Date:  1991-09-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  AIM; IM    
Cardiac Surgical Unit, University of Edinburgh Medical School, Scotland.
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MeSH Terms
Heart-Assist Devices*
Heparin / administration & dosage*
Thrombolytic Therapy / methods*
Thrombosis / prevention & control*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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