Document Detail

Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators.
MedLine Citation:
PMID:  8237823     Owner:  NLM     Status:  MEDLINE    
Sodium channel blockers and class III antiarrhythmic compounds, as well as beta blockers, have been used in preventing recurrences of sudden cardiac death. In recent years, implantable cardioverter-defibrillators (ICDs) have been used increasingly, but no data from randomized trials comparing antiarrhythmic drug and ICD therapy have been reported in this setting. In 1987, the Cardiac Arrest Study Hamburg (CASH), a prospective, randomized trial, was initiated to compare metoprolol, amiodarone, propafenone, and ICD implantation in patients surviving sudden cardiac death due to documented ventricular tachycardia and/or ventricular fibrillation. The details of the study design and preliminary results are presented herein. The primary endpoint of the study is total mortality. The data reviewed in March 1992, representing a mean follow-up period of 11 months, indicated no significant differences among patients randomized to metoprolol, amiodarone, and ICDs. However, there was a significantly higher total mortality and cardiac arrest recurrence in patients randomized to propafenone compared with those randomized to the ICD treatment limb. The study continues with the deletion of the propafenone treatment limb.
J Siebels; R Cappato; R Rüppel; M A Schneider; K H Kuck
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  72     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-12-21     Completed Date:  1993-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109F-113F     Citation Subset:  AIM; IM    
Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany.
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MeSH Terms
Amiodarone / therapeutic use
Anti-Arrhythmia Agents / therapeutic use*
Death, Sudden, Cardiac / etiology,  prevention & control*
Defibrillators, Implantable*
Heart Arrest / etiology,  prevention & control*
Metoprolol / therapeutic use
Middle Aged
Multivariate Analysis
Propafenone / therapeutic use
Prospective Studies
Regression Analysis
Tachycardia, Ventricular / complications
Ventricular Fibrillation / complications
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 37350-58-6/Metoprolol; 54063-53-5/Propafenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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