| Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators. | |
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MedLine Citation:
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PMID: 8237823 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sodium channel blockers and class III antiarrhythmic compounds, as well as beta blockers, have been used in preventing recurrences of sudden cardiac death. In recent years, implantable cardioverter-defibrillators (ICDs) have been used increasingly, but no data from randomized trials comparing antiarrhythmic drug and ICD therapy have been reported in this setting. In 1987, the Cardiac Arrest Study Hamburg (CASH), a prospective, randomized trial, was initiated to compare metoprolol, amiodarone, propafenone, and ICD implantation in patients surviving sudden cardiac death due to documented ventricular tachycardia and/or ventricular fibrillation. The details of the study design and preliminary results are presented herein. The primary endpoint of the study is total mortality. The data reviewed in March 1992, representing a mean follow-up period of 11 months, indicated no significant differences among patients randomized to metoprolol, amiodarone, and ICDs. However, there was a significantly higher total mortality and cardiac arrest recurrence in patients randomized to propafenone compared with those randomized to the ICD treatment limb. The study continues with the deletion of the propafenone treatment limb. |
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Authors:
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J Siebels; R Cappato; R Rüppel; M A Schneider; K H Kuck |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: The American journal of cardiology Volume: 72 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-12-21 Completed Date: 1993-12-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 109F-113F Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, University Hospital Eppendorf, Hamburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amiodarone / therapeutic use Anti-Arrhythmia Agents / therapeutic use* Death, Sudden, Cardiac / etiology, prevention & control* Defibrillators, Implantable* Female Heart Arrest / etiology, prevention & control* Humans Male Metoprolol / therapeutic use Middle Aged Multivariate Analysis Propafenone / therapeutic use Prospective Studies Regression Analysis Tachycardia, Ventricular / complications Ventricular Fibrillation / complications |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 1951-25-3/Amiodarone; 37350-58-6/Metoprolol; 54063-53-5/Propafenone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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