| Preliminary report: indications of improved visual function after retinal sheet transplantation in retinitis pigmentosa patients. | |
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MedLine Citation:
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PMID: 10511047 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To report indications of new visual function after retinal transplantation in two blind patients with retinitis pigmentosa. METHODS: Intact sheets of fetal retina (15 and 17 weeks gestational age) were transplanted subretinally (between the neurosensory retina and the retinal pigment epithelium) near the fovea in the left eye of a 23-year-old white man (Patient A) and in the left eye of a 72-year-old white woman (Patient B), both with autosomal-recessive retinitis pigmentosa. RESULTS: Postoperatively, at 6 and 5 months, respectively, both patients reported new visual sensation in the visual field corresponding to the transplant. In both patients, the visual sensation continued to be present after transplantation, at 12 and 8 months, respectively. In Patient A, a transient multifocal electroretinography (mfERG) response was observed in the transplant area 4 months postoperatively but was not detectable in Patient A at 6.0 and 9.5 months post-retinal transplantation. In Patient B, no positive mfERG responses were seen up to 5 months postoperatively. No rejection (presenting as cystoid macular edema, macular pucker, and extensive intraretinal edema with disrupted retinal pigment epithelium) to the transplanted tissue was seen up to 13 months in Patient A and 9 months in Patient B by fluorescein angiography. CONCLUSION: Transplantation of intact sheets of fetal human retina in two patients with retinitis pigmentosa was not associated with evidence of transplant rejection. Subjective improvement and an indication of objective improvement 4 months postoperatively were seen in Patient A, and subjective improvement only was seen in Patient B. |
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Authors:
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N D Radtke; R B Aramant; M Seiler; H M Petry |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of ophthalmology Volume: 128 ISSN: 0002-9394 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-08 Completed Date: 1999-10-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 384-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Kentucky, USA. NRADTKE@prodigy.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blindness / etiology Electroretinography Female Fetal Tissue Transplantation* Fluorescein Angiography Gestational Age Graft Survival Humans Male Retina / physiopathology, transplantation* Retinitis Pigmentosa / complications, genetics, physiopathology, surgery* Visual Acuity* / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01EY08519/EY/NEI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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