Document Detail


Preliminary observations on the pharmacology of petaline chloride, a quaternary alkaloid from Leontice leontopetalum.
MedLine Citation:
PMID:  2606323     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Low concentrations of petaline chloride (1-300 micrograms/ml) caused relaxation of the epinephrine-contracted aorta, contraction of the ileum, and no effect on the trachea. 2. Larger concentrations (up to 3 mg/ml) caused nonsustained large contractions of the aorta and the trachea and increased the amplitude of the phasic contractions of the ileum. 3. The above effects were not inhibited in the presence of atropine. 4. Petaline chloride increased, in a concentration-dependent manner, the contractions of the spontaneously-beating atrium and the isolated perfused heart. 5. The effects of petaline chloride on the atrium and on the perfused heart were not affected by propranolol but were significantly reduced in the presence of quinacrine, suggesting the participation of arachidonic acid metabolism to this effect. 6. In anesthetized rats, petaline chloride (0.3-3 mg/100 g body weight; i.p.) increased both the systolic and diastolic blood pressure and increased the heart rate.
Authors:
S Abdalla; M Abu-Zarga; S Sabri
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  General pharmacology     Volume:  20     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1989  
Date Detail:
Created Date:  1990-02-21     Completed Date:  1990-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  565-9     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Faculty of Science, University of Jordan, Amman.
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MeSH Terms
Descriptor/Qualifier:
Alkaloids / pharmacology*
Animals
Blood Pressure / drug effects
Cardiotonic Agents
Guinea Pigs
Heart Rate / drug effects
Isoquinolines / pharmacology*
Male
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Muscle, Smooth, Vascular / drug effects
Myocardial Contraction / drug effects
Plants, Medicinal / analysis*
Propranolol / pharmacology
Quinacrine / pharmacology
Rats
Chemical
Reg. No./Substance:
0/Alkaloids; 0/Cardiotonic Agents; 0/Isoquinolines; 525-66-6/Propranolol; 64057-59-6/petaline; 83-89-6/Quinacrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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