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Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.
MedLine Citation:
PMID:  20960579     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13-26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum. Copyright © 2010 John Wiley & Sons, Ltd.
Authors:
Jens H Jensen; Maria F Falangola; Caixia Hu; Ali Tabesh; Otto Rapalino; Calvin Lo; Joseph A Helpern
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Publication Detail:
Type:  Journal Article     Date:  2010-10-19
Journal Detail:
Title:  NMR in biomedicine     Volume:  24     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY, USA; Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY, USA. jj33@nyu.edu.
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