Document Detail


Preliminary observations on the effect of hypoxic and hyperbaric stress on pulmonary gas exchange in breath-hold divers.
MedLine Citation:
PMID:  21848113     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
AIM: To evaluate pulmonary alveolar-capillary membrane integrity and ventilation/perfusion mismatch after breath-hold diving.
METHODS: Pulmonary diffusing capacity to carbon monoxide (DLCO) and nitric oxide (DLNO), haemoglobin (Hb) and haematocrit (Hct) were measured in six elite divers before and at 2, 10 and 25 minutes after a maximal breath-hold dive to a depth of 10 metres' sea water.
RESULTS: Compared to pre-dive, DLCO showed a slight increase at 2 minutes in five subjects and a tendency to decrease at 25 minutes (P < 0.001) in all subjects. DLNO showed an increase at 10 minutes in three divers and a slight decrease at 25 minutes in five subjects. There was a small but significant (P < 0.001) increase in Hb and Hct at 2 minutes, possibly affecting the DLCO measurements.
CONCLUSIONS: An early but transient increase in DLCO in five divers may reflect the central shift in blood volume during a breath-hold dive. The late parallel decrease in DLCO and DLNO likely reflects alveolar-capillary distress (interstitial oedema). The DLNO increase in three subjects at 10 minutes may suggest ventilation/perfusion mismatch.
Authors:
Erika Garbella; Andrea Piarulli; Edo Fornai; Alessandro Pingitore; Renato Prediletto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diving and hyperbaric medicine : the journal of the South Pacific Underwater Medicine Society     Volume:  41     ISSN:  1833-3516     ISO Abbreviation:  Diving Hyperb Med     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101282742     Medline TA:  Diving Hyperb Med     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  97-100     Citation Subset:  IM    
Affiliation:
Extreme Center, Scuola Superiore, Sant'Anna and National Research Council-Tuscany Region "Gabriele Monasterio" Foundation, Pisa, Italy.
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