| Preliminary observations on the effect of amitriptyline treatment in preventing syncope recurrence in patients with vasovagel syncope. | |
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MedLine Citation:
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PMID: 17593184 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Vasovagal syncope is a common and challenging problem that may result in injury and causes substantial anxiety among patients and their relatives. However, treatment of vasovagal syncope with standard pharmacologic approaches is not satisfactory. The aim of this study is to investigate the effect of amitriptyline, a tricyclic antidepressant drug, by using its anticholinergic effects in preventing syncopal episodes in patients with vasovagal syncope. METHODS: In this study, 74 patients (mean age 24 +/- 1.9 years, 26 male) with a history of recurrent syncope and baseline positive head-up tilt table test (syncope or presyncope) were included. Oral amitriptyline treatment was given to all patients, with a starting dose of 10 mg once a day. Head-up tilt table test was performed in all patients 4 weeks after the treatment started. Patients were followed up clinically for 6 months. RESULTS: After 4 weeks, during head-up tilt table test in 69 patients (93%), syncope or presyncope was not seen and test was assumed as negative. At the end of the 6th month, 67 patients (91%) were free of symptoms. Only two patients (0.3%) did not tolerate amitriptyline due to side effects. CONCLUSIONS: Oral amitriptyline can be used in the prevention of recurrent episodes of vasovagal syncope safely. However, randomized controlled studies are essential to assess the real effectiveness of this therapy. |
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Authors:
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Ergün Bariş Kaya; Gülcan Abali; Kudret Aytemir; Sedat Köse; Uğur Kocabaş; Lale Tokgözoğlu; Giray Kabakçi; Basri Amasyali; Hilmi Ozkutlu; Nasih Nazli; Ali Oto |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 12 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-06-26 Completed Date: 2007-07-31 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 153-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey. doctorkaya@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adrenergic Uptake Inhibitors / administration & dosage, therapeutic use* Adult Amitriptyline / administration & dosage, therapeutic use* Female Humans Male Recurrence / prevention & control Syncope, Vasovagal / prevention & control* Tilt-Table Test Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Uptake Inhibitors; 50-48-6/Amitriptyline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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