Document Detail

Preliminary investigation of lethally toxic sera of sudden infant death syndrome victims and neutralisation by commercially available immunoglobulins and adult sera.
MedLine Citation:
PMID:  10443508     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to test the hypotheses (i) that sudden infant death syndrome sera are toxic to 11-day old chick embryos and (ii) that such a toxicity can be counteracted by immunoglobulin or adult sera. Serum samples from 11 SIDS victims and five controls were tested for lethal toxicity in the chick embryo bioassay. Five serum samples were used to challenge chick embryos injected with the following: sudden infant death syndrome serum plus Hank's balanced salt solution; Hank's balanced salt solution alone; sudden infant death syndrome serum plus 3% w/v commercial immunoglobulin; sudden infant death syndrome serum plus 6% w/v immunoglobulin; sudden infant death syndrome serum plus pooled sera of 40 healthy adults. Results obtained revealed that Hank's balanced salt solution, the pooled adult serum and the commercial immunoglobulin were all non-lethal, in the chick embryo test system. By contrast. 10 sudden infant death syndrome victims yielded sera containing lethal levels of toxin(s) compared to 2/5 controls which was statistically significant (P < 0.05, Fischer's exact test). In the tests of sudden infant death syndrome serum plus immunoglobulin or pooled adult serum, the lethality of sudden infant death syndrome serum was abolished in all cases. The reduction in toxicity of individual sudden infant death syndrome serum plus immunoglobulin or pooled adult serum was often statistically significant (P<0.05-P<0.00005, Fischer's exact test). We conclude that lethal levels of toxin are present in sudden infant death syndrome sera and that they can be neutralised by normal immune serum. These results indicate that passive immunisation is a potential treatment to protect babies considered at risk from sudden infant death syndrome.
N M Sayers; D B Drucker; I V Hutchinson; A J Barson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEMS immunology and medical microbiology     Volume:  25     ISSN:  0928-8244     ISO Abbreviation:  FEMS Immunol. Med. Microbiol.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-14     Completed Date:  1999-10-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9315554     Medline TA:  FEMS Immunol Med Microbiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
School of Biological Sciences, University of Manchester, UK.
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MeSH Terms
Bacterial Toxins / blood*,  immunology*
Chick Embryo
Death, Sudden
Immunoglobulins / immunology*
Infant, Newborn
Neutralization Tests
Sudden Infant Death / blood*
Reg. No./Substance:
0/Bacterial Toxins; 0/Immunoglobulins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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