Document Detail


Preliminary in vivo evaluation of a novel intrasaccular cerebral aneurysm occlusion device.
MedLine Citation:
PMID:  24891454     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: Current endovascular technology does not offer a perfect solution for all cerebral aneurysms. Our group has built two versions of a novel aneurysm intrasaccular occlusion device (AIOD) to address the drawbacks associated with current occlusion devices. The objective of the present study was to perform pilot proof of concept in vivo testing of this new AIOD in swine and canines.
METHODS: Two configurations of the AIOD, termed 'coil-in-shell' and 'gel-in-shell', were implanted in surgically created sidewall aneurysms (n=4) in swine for acute occlusion studies, as well as sidewall (n=8) and bifurcation aneurysms (n=3) in canines to assess long term occlusion efficacy. Occlusion at all time points (immediate, 6 weeks, and 12 weeks) was evaluated by angiography. Neointimal healing at 12 weeks post-implantation in canines was examined histologically.
RESULTS: Angiographic analysis showed that both the coil-in-shell and gel-in-shell devices achieved complete aneurysm occlusion immediately following device delivery in sidewall aneurysms in swine. In longer term canine studies, initial occlusion ranged from 71.3% to 100%, which was stable with no recurrence in any of the sidewall aneurysms at 6 or 12 weeks. Histological analysis at 12 weeks showed mature fibromuscular tissue at the neck of all aneurysms and no significant inflammatory response.
CONCLUSIONS: The AIOD tested in this study showed promise in terms of acute and chronic occlusion of aneurysms. Our findings suggest that these devices have the potential to promote robust tissue healing at the aneurysm neck, which may minimize aneurysm recurrence. Although proof of principle has been shown, further work is needed to deliver this device through an endovascular route.
Authors:
Roham Moftakhar; Fangmin Xu; Beverly Aagaard-Kienitz; Daniel W Consigny; Julie R Grinde; Kevin Hart; Claire E Flanagan; Wendy C Crone; Kristyn S Masters
Related Documents :
22746394 - A new genus and species of lungworm (nemata: metastrongyloidea) from akodon mollis thom...
24824494 - Aortic valve replacement for quadricuspid valve: a lesson learnt from a negative experi...
24296984 - The use of robotic endovascular catheters in the facilitation of transcatheter aortic v...
3782544 - Kissing intrasellar carotid arteries in acromegaly: ct demonstration.
25348824 - K(+) channels expression in hypertension after arterial injury, and effect of selective...
6215214 - Vectorcardiographic and hemodynamic correlation in chronic obstructive pulmonary disease.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-2
Journal Detail:
Title:  Journal of neurointerventional surgery     Volume:  -     ISSN:  1759-8486     ISO Abbreviation:  J Neurointerv Surg     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101517079     Medline TA:  J Neurointerv Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Analysis of short-term total hospital costs and current primary cost drivers of coiling versus clipp...
Next Document:  Vgll1 expression is associated with a triple-negative basal-like phenotype in breast cancer.