Document Detail


Preliminary immunohistochemical investigations of thyroid C cells in an experimental model of hyperthyroidism.
MedLine Citation:
PMID:  14655110     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of the parafollicular (C) cells, the second most important cells in the thyroid gland, has not hitherto been clarified. They are considered to be disperse neuroendocrine cells of the APUD system and synthesise and release many of the regulatory peptides. Few publications are concerned with the evaluation of the structure and function of C cells in the thyroid gland or the probable relationship between these cells and the follicular cells in physiological and pathological conditions. For this reason immunohistochemical investigations were carried out into the activity of the C cells in rats in an experimental model of hyperthyroidism caused by chronic thyroxine influence. This C-cell activity was then evaluated. Differences in the quantity, distribution and calcitonin immunoreactivity of C cells were observed in hyperthyroid rats in comparison to the control group, together with a significant diminution of plasma TSH and calcitonin levels. Our preliminary study may indicate a functional interaction between follicular and parafollicular cells in the thyroid gland.
Authors:
Jacek Dadan; Robert Ł Zbucki R; Bogusław Sawicki; Izabela Bialuk; Agnieszka Zawadzka; Maria M Winnicka; Zbigniew Puchalski
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Folia morphologica     Volume:  62     ISSN:  0015-5659     ISO Abbreviation:  Folia Morphol. (Warsz)     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-05     Completed Date:  2004-01-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374620     Medline TA:  Folia Morphol (Warsz)     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  319-21     Citation Subset:  IM    
Affiliation:
1st Department of General and Endocrinological Surgery, Medical University, Białystok, Poland. klchirog@amb.edu.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / analysis
Calcitonin / blood
Disease Models, Animal
Hyperthyroidism / chemically induced,  metabolism,  pathology*
Immunohistochemistry
Injections, Intraperitoneal
Male
Rats
Rats, Wistar
Thyroid Gland / drug effects,  metabolism,  pathology*
Thyrotropin / blood
Thyroxine / administration & dosage,  pharmacology
Chemical
Reg. No./Substance:
0/Biological Markers; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9007-12-9/Calcitonin

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