Document Detail

Preliminary immunohistochemical investigations of human thyroid C cells in the simple and hyperactive nodular goitre.
MedLine Citation:
PMID:  11374819     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to carry out histomorphological and immunohistochemical analysis of thyroid C cells in 30 patients with simple goitre and hyperactive goitre including Graves-Basedow (G-B) disease, treated surgically. Four tissue samples were always taken from the same internal parts of the gland where the number of C cells in physiological conditions was the highest. C cells were detected in paraffin sections after impregnation with silver salt (Grimelius method) or immunohistochemically, with antibodies against calcitonin, synaptophysin, chromogranin A and neuron-specific enolase. Distinctly less numerous C cells were found in simple and hyperactive goitre than in normal thyroid parenchyma. The majority of C cells showed weak intensity of the examined immunohistochemical reactions. C cells were not observed at all in the texture of nodules well separated by the connective tissue. Proliferative changes concerned only follicular cells.
J Dadan; B Sawicki; L Chyczewski; A Azzadin; H Malla; J Dziecioł; Z Puchalski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society     Volume:  39     ISSN:  0239-8508     ISO Abbreviation:  Folia Histochem. Cytobiol.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-25     Completed Date:  2001-10-11     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8502651     Medline TA:  Folia Histochem Cytobiol     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  189-90     Citation Subset:  IM    
1st Department of General Surgery, Medical Academy, Białystok, Poland.
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MeSH Terms
Goiter, Nodular / pathology*,  surgery
Graves Disease / pathology
Middle Aged
Thyroid Gland / pathology*,  surgery

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