Document Detail


Preliminary experience with the smooth muscle troponin-like protein, calponin, as a novel biomarker for diagnosing acute aortic dissection.
MedLine Citation:
PMID:  18436559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: The early diagnosis of acute aortic dissection (AD) remains challenging. We sought to determine the utility of the troponin-like protein of smooth muscle, calponin, as a diagnostic biomarker of acute AD. METHODS AND RESULTS: Immunoassays against calponin (acidic, basic, and neutral isoforms) were developed and the levels were compared in a convenience sample of 59 patients with radiographically proven AD [34 males, age 59 +/- 15 (SD) years] vs. 158 patients suspected of having AD at presentation (116 males, age 63 +/- 15 years) but whose final diagnosis was not AD. Basic calponin, which is the most specific and abundant in smooth muscle, and acidic calponin, respectively, showed greater than two-fold and three-fold elevations in patients with acute AD. Diagnostic performance as determined by receiver-operating characteristics curve analysis showed that both acidic and basic calponin have the potential to detect AD in the first 24 h [respective areas under the curve (AUCs) 0.63 and 0.58], with superior performance of basic calponin (when compared with acidic) in the initial 6 h (respective AUCs 0.63 and 0.67). CONCLUSION: Circulating calponin levels were elevated in acute AD compared with controls. These biomarkers have the potential for use as an early diagnostic biomarker for acute AD.
Authors:
Toru Suzuki; Alessandro Distante; Antonella Zizza; Santi Trimarchi; Massimo Villani; Jorge Antonio Salerno Uriarte; Luigi de Luca Tupputi Schinosa; Attilio Renzulli; Federico Sabino; Richard Nowak; Robert Birkhahn; Judd E Hollander; Francis Counselman; Eduardo Bossone; Kim Eagle;
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2008-04-24
Journal Detail:
Title:  European heart journal     Volume:  29     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-05     Completed Date:  2008-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1439-45     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. torusuzu-tky@umin.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aneurysm, Dissecting / diagnosis*
Aortic Aneurysm / diagnosis*
Biological Markers / analysis
Calcium-Binding Proteins / analysis*,  chemistry
Female
Humans
Immunoassay / methods
Male
Microfilament Proteins / analysis*,  chemistry
Middle Aged
ROC Curve
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Calcium-Binding Proteins; 0/Microfilament Proteins; 0/calponin
Investigator
Investigator/Affiliation:
Kim A Eagle / ; Alessandro Distante / ; Toru Suzuki / ; Angela M Mills / ; Judd E Hollander / ; Richard Nowak / ; Robert Birkhahn / ; Francis Counselman / ; Frank Peacock / ; Craig Basson / ; Arturo Evangelista / ; Carlo Rosen / ; Natan Shapiro / ; Robert Siegel / ; Adam Singer / ; Antonella Zizza / ; Federico Sabino / ; Isabella Longo / ; Stefano Lagravinese / ; Rosaria Galdi / ; Elena Gianicolo / ; Eduardo Bossone / ; Enzo Sbenaglia / ; Santi Trimarchi / ; Viviana Grassi / ; Massimo Villani / ; Paolo Fellini / ; Silvano Fracella / ; Francesco Magliari / ; Massimiliano Garzya / ; Jorge Antonio Salerno Uriarte / ; Matteo Tozzi / ; Alberto Limido / ; Luigi Tupputi De Luca / ; Vito Paradiso / ; Andreas Paramithiotis / ; Attilio Renzulli / ; Egidio Bevacqua / ; Barbara Impiombato / ; Stefano Messina / ; Saverio Rega / ; Filippo Crea / ; Federica Tarantino / ; Giuseppe Di Benedetto / ; Antonello Panza / ; Giampiero Esposito / ; Rocco Antonio Pennetta / ; Paolo Righini / ; Ettore De Lorenzi / ; Giovanni De Rinaldis / ; Giordano Calabrese / ; Pietro De Angelis / ; Roberto Chiesa / ; Gloria Esposito / ; Gianfranco Ignone / ; Piergiovanni Crocco / ; Giuseppe Rosato / ; Giovanni Stanco / ; Marcello Costantini / ; Ernesto Lupo / ; Jim Froehlich / ; Daigo Sawaki / ; Ryozo Nagai /

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